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Tbio
GJB3
Gap junction beta-3 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373362
  • ENSP00000362460
  • ENSG00000188910
  • ENST00000373366
  • ENSP00000362464

Symbol
  • CX31
  • EKV
  • CX31
  • DFNA2
  • EKVP1
  • DFNA2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.89
transcription factor perturbation
0.74
protein domain
0.73
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.01   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.01   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
KCNQ4
Tclin
Family:  IC
Novelty:  0.00626926
Score:  0.8
Data Source:  STRINGDB
RPL34
Tbio
Novelty:  0.02236592
Score:  0.8
Data Source:  STRINGDB
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.791
Data Source:  STRINGDB
COCH
Tbio
Novelty:  0.00819355
Score:  0.731
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.699
Data Source:  STRINGDB
GJE1
Tdark
Novelty:  0.03519662
Score:  0.661
Data Source:  STRINGDB
PKP1
Tbio
Novelty:  0.0100609
Score:  0.61
Data Source:  STRINGDB
GJB4
Tbio
Novelty:  0.02165123
Score:  0.593
Data Source:  STRINGDB
GJA1
Tbio
Novelty:  0.00021332
Score:  0.591
Data Source:  STRINGDB
GJB5
Tbio
Novelty:  0.04928204
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
66.8
platelet crit
1
1
1
48.5
myeloid white cell count
1
1
1
48.5
intraocular pressure measurement
1
1
0
6.2
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
66.8
platelet crit
1
48.5
myeloid white cell count
1
48.5
intraocular pressure measurement
0
6.2
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gap junction protein beta 3
710834
Mouse
MGI:95721
14620
Rat
RGD:2695
29585
Dog
gap junction protein beta 3
VGNC:41239
482486
Horse
gap junction protein beta 3
VGNC:18356
100055573
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gap junction protein beta 3
Mouse
Rat
Dog
gap junction protein beta 3
Horse
gap junction protein beta 3
Publication Statistics
PubMed Score 147.01
PubMed score by year
PubTator Score 112.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title