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Tbio
GJA3
Gap junction alpha-3 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241125
  • ENSP00000241125
  • ENSG00000121743

Symbol
  • CX46
  • CZP3
  • CTRCT14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
protein domain
0.73
cell type or tissue
0.68
tissue sample
0.64
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.96   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.96   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
CRYBB2
Tbio
Novelty:  0.00721869
Score:  0.921
Data Source:  STRINGDB
CRYBB1
Tbio
Novelty:  0.01083645
Score:  0.857
Data Source:  STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.85
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.85
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.835
Data Source:  STRINGDB
MIP
Tbio
Novelty:  0.00299543
Score:  0.829
Data Source:  STRINGDB
CRYBA1
Tbio
Novelty:  0.02788955
Score:  0.818
Data Source:  STRINGDB
CRYGC
Tbio
Novelty:  0.00083924
Score:  0.8
Data Source:  STRINGDB
CRYBB3
Tbio
Novelty:  0.0455879
Score:  0.793
Data Source:  STRINGDB
CRYGD
Tbio
Novelty:  0.00246109
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
54.4
grip strength measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
54.4
grip strength measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95714
14611
Rat
RGD:621820
79217
Dog
gap junction protein alpha 3
VGNC:41233
486052
Horse
gap junction protein alpha 3
VGNC:18350
100050019
Cow
gap junction protein alpha 3
VGNC:29372
100140301
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gap junction protein alpha 3
Horse
gap junction protein alpha 3
Cow
gap junction protein alpha 3
Publication Statistics
PubMed Score 166.96
PubMed score by year
PubTator Score 102.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title