Tbio GIT1 ARF GTPase-activating protein GIT1

Protein Summary

Description

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).

Uniprot Accession IDs

• Q9Y2X7
• B4DGU9
• B4DSV3
• Q86SS0
• Q9BRJ4
• ARF GAP GIT1

Gene Name

• GIT1

Ensembl ID

• ENST00000225394
• ENSP00000225394
• ENSG00000108262
• ENST00000394869
• ENSP00000378338

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.85
small molecule perturbation	0.75
transcription factor binding site profile	0.74
protein domain	0.73
transcription factor	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.77   (req: < 5)

Gene RIFs: 47   (req: <= 3)

Antibodies: 441   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.77   (req: >= 5)

Gene RIFs: 47   (req: > 3)

Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0