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Tbio
GIMAP2
GTPase IMAP family member 2

Protein Summary
Description
The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself. This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223293
  • ENSP00000223293
  • ENSG00000106560

Symbol
  • IMAP2
  • IAN12
  • IMAP2
  • HIMAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
tissue sample
0.77
molecular function
0.73
virus perturbation
0.64
tissue
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
TOR1B
Tbio
Novelty:  0.00611826
p_int:  0.941098699
p_ni:  0.058901301
Score:  0.519
Data Source:  BioPlex,STRINGDB
STOM
Tbio
Novelty:  0.00459891
p_int:  0.925061667
p_ni:  0.074938333
Score:  0.534
Data Source:  BioPlex,STRINGDB
FBP1
Tchem
Family:  Enzyme
Novelty:  0.0029987
p_int:  0.877370699
p_ni:  0.122629299
p_wrong:  2e-9
Score:  0.203
Data Source:  BioPlex,STRINGDB
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.849592375
p_ni:  0.150407625
Score:  0.189
Data Source:  BioPlex,STRINGDB
AIG1
Tbio
Novelty:  0.05745221
Score:  0.58
Data Source:  STRINGDB
GIMAP7
Tbio
Family:  Enzyme
Novelty:  0.15758026
Score:  0.558
Data Source:  STRINGDB
UBAC2
Tbio
Novelty:  0.13384376
Score:  0.553
Data Source:  STRINGDB
KLRC4
Tbio
Novelty:  0.16922525
Score:  0.48
Data Source:  STRINGDB
TMEM200B
Tdark
Novelty:  0.18113379
Score:  0.473
Data Source:  STRINGDB
VMA21
Tdark
Family:  Enzyme
Novelty:  0.46129032
Score:  0.465
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
3
83.2
lymphocyte count
2
2
2
69.2
fibrinogen measurement
2
2
2
68
high density lipoprotein cholesterol measurement
2
2
2
59.5
Oral ulcer
1
1
0
1
42.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
83.2
lymphocyte count
2
69.2
fibrinogen measurement
2
68
high density lipoprotein cholesterol measurement
2
59.5
Oral ulcer
0
1
42.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTPase, IMAP family member 2
VGNC:4371
463897
Macaque
GTPase, IMAP family member 2
713463
Dog
GTPase, IMAP family member 2
VGNC:41216
482797
Horse
GTPase IMAP family member 2-like
100057398
Pig
GTPase, IMAP family member 2
100523477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTPase, IMAP family member 2
Macaque
GTPase, IMAP family member 2
Dog
GTPase, IMAP family member 2
Horse
GTPase IMAP family member 2-like
Pig
GTPase, IMAP family member 2
Publication Statistics
PubMed Score 18.55
PubMed score by year
PubTator Score 6.63
PubTator score by year
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Related Publications
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PMID
Year
Title