You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GIGYF1
GRB10-interacting GYF protein 1

Protein Summary
Description
May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and insulin receptors and regulates receptor signaling. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275732
  • ENSP00000275732
  • ENSG00000146830
  • ENST00000646601
  • ENSP00000494292

Symbol
  • CDS2
  • PERQ1
  • GYF1
  • PERQ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
interacting protein
0.85
cellular component
0.8
microRNA
0.78
phenotype
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
EIF4E2
Tbio
Novelty:  0.0490219
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999095527
p_ni:  0.000018506
p_wrong:  0.000885967
Score:  0.529
Data Source:  BioPlex,STRINGDB
GRB10
Tbio
Novelty:  0.00762794
Score:  0.966
Data Source:  STRINGDB
CNOT4
Tbio
Novelty:  0.01939346
Score:  0.773
Data Source:  STRINGDB
LENG8
Tdark
Novelty:  0.66682078
Score:  0.76
Data Source:  STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
Score:  0.736
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.734
Data Source:  STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
Score:  0.714
Data Source:  STRINGDB
NUMA1
Tbio
Novelty:  0.00158543
Score:  0.659
Data Source:  STRINGDB
SH3BP4
Tbio
Novelty:  0.13130398
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
8
13
17
99.6
hemoglobin measurement
4
10
15
99.5
mean corpuscular hemoglobin concentration
6
5
6
99.3
red blood cell distribution width
4
5
9
99
erythrocyte count
7
6
9
98.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
17
99.6
hemoglobin measurement
15
99.5
mean corpuscular hemoglobin concentration
6
99.3
red blood cell distribution width
9
99
erythrocyte count
9
98.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GRB10 interacting GYF protein 1
712775
Mouse
MGI:1888677
57330
Rat
RGD:1309933
304378
Dog
GRB10 interacting GYF protein 1
VGNC:41213
489833
Cow
GRB10 interacting GYF protein 1
VGNC:29355
532406
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GRB10 interacting GYF protein 1
Mouse
Rat
Dog
GRB10 interacting GYF protein 1
Cow
GRB10 interacting GYF protein 1
Publication Statistics
PubMed Score 5.79
PubMed score by year
PubTator Score 1.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title