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Tbio
GID8
Glucose-induced degradation protein 8 homolog

Protein Summary
Description
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266069
  • ENSP00000266069
  • ENSG00000101193

Symbol
  • C20orf11
  • TWA1
  • TWA1
  • C20orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.89
transcription factor perturbation
0.84
microRNA
0.72
PubMedID
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.989999363
p_ni:  0.010000637
Data Source:  BioPlex
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.987881985
p_ni:  0.012118015
Score:  0.547
Data Source:  BioPlex,STRINGDB
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.984003378
p_ni:  0.015996621
p_wrong:  1e-9
Data Source:  BioPlex
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.981752038
p_ni:  0.018247962
Data Source:  BioPlex
PIGT
Tbio
Family:  Enzyme
Novelty:  0.02539879
p_int:  0.965733172
p_ni:  0.034266827
p_wrong:  1e-9
Data Source:  BioPlex
GCG
Tchem
Novelty:  0.00004879
p_int:  0.953960302
p_ni:  0.046039698
Data Source:  BioPlex
CST8
Tbio
Novelty:  0.02316886
p_int:  0.951524294
p_ni:  0.048475706
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.936320732
p_ni:  0.063679266
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.933126872
p_ni:  0.066873128
Data Source:  BioPlex
NMB
Tbio
Novelty:  0.00729571
p_int:  0.929395808
p_ni:  0.070604192
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
48.5
age at menopause
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
48.5
age at menopause
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GID complex subunit 8 homolog
VGNC:9864
469997
Macaque
GID complex subunit 8 homolog
698189
Mouse
MGI:1923675
76425
Dog
GID complex subunit 8 homolog
VGNC:41211
488056
Horse
GID complex subunit 8 homolog
VGNC:18337
100051346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GID complex subunit 8 homolog
Macaque
GID complex subunit 8 homolog
Mouse
Dog
GID complex subunit 8 homolog
Horse
GID complex subunit 8 homolog
Publication Statistics
PubMed Score 6.94
PubMed score by year
PubTator Score 5.64
PubTator score by year
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Related Publications
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PMID
Year
Title