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Tbio
GHITM
Growth hormone-inducible transmembrane protein

Protein Summary
Description
Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372134
  • ENSP00000361207
  • ENSG00000165678

Symbol
  • DERP2
  • MICS1
  • TMBIM5
  • DERP2
  • MICS1
  • My021
  • PTD010
  • TMBIM5
  • HSPC282
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
gene perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 299.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
SARM1
Tchem
Novelty:  0.00510488
p_int:  0.99999997
p_ni:  3e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
C12orf73
Tdark
Novelty:  8.60557769
p_int:  0.999999683
p_wrong:  3.17e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
MFN2
Tbio
Novelty:  0.00137876
p_int:  0.999999666
p_ni:  3.34e-7
Score:  0.458
Data Source:  BioPlex,STRINGDB
MTFR1L
Tdark
Novelty:  3.23781609
p_int:  0.999969125
p_ni:  0.000030874
Data Source:  BioPlex
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
p_int:  0.999944262
p_ni:  0.000055738
Data Source:  BioPlex
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.999934942
p_ni:  0.000065058
Data Source:  BioPlex
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
p_int:  0.999673331
p_ni:  0.000326669
Data Source:  BioPlex
FNDC4
Tbio
Novelty:  0.31597146
p_int:  0.999274703
p_ni:  0.000725297
Data Source:  BioPlex
SELENOH
Tbio
Novelty:  0.02421467
p_int:  0.998827349
p_ni:  0.001172639
p_wrong:  1.3e-8
Score:  0.168
Data Source:  BioPlex,STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.997529292
p_ni:  0.002470708
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
8.3
71.8
age at onset
1
1
0
8.3
27.3
Myopia
1
1
0
8.3
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
8.3
71.8
age at onset
0
8.3
27.3
Myopia
0
8.3
27.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone inducible transmembrane protein
VGNC:3866
450562
Macaque
growth hormone inducible transmembrane protein
702691
Mouse
MGI:1913342
66092
Rat
RGD:1359301
290596
Dog
growth hormone inducible transmembrane protein
VGNC:41205
479266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone inducible transmembrane protein
Macaque
growth hormone inducible transmembrane protein
Mouse
Rat
Dog
growth hormone inducible transmembrane protein
Publication Statistics
PubMed Score 299.94
PubMed score by year
PubTator Score 32.91
PubTator score by year
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Related Publications
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PMID
Year
Title