Tbio GH1 Somatotropin

Protein Summary

Description

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01241
• A6NEF6
• Q14405
• Q16631
• Q5EB53
• Q9HBZ1
• Q9UMJ7
• Q9UNL5

Gene Name

• GH1

Ensembl ID

• ENST00000323322
• ENSP00000312673
• ENSG00000259384
• ENST00000351388
• ENSP00000343791
• ENST00000458650
• ENSP00000408486

Symbol

• GH
• GHN
• GH-N
• GHB5
• IGHD2
• hGH-N
• IGHD1A
• IGHD1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.94
disease	0.9
biological process	0.88
phenotype	0.75
biological term	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Somatotropin

Protein / Signaling Molecule / Growth Factor / Somatotropin

DTO Classes

Protein / Signaling / Growth Factor / Somatotropin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.22   (req: < 5)

Gene RIFs: 375   (req: <= 3)

Antibodies: 1244   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1221.22   (req: >= 5)

Gene RIFs: 375   (req: > 3)

Antibodies: 1244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0