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Tbio
GGT7
Glutathione hydrolase 7

Protein Summary
Description
Cleaves glutathione conjugates. This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336431
  • ENSP00000338964
  • ENSG00000131067

Symbol
  • GGTL3
  • GGTL5
  • GGT4
  • GGTL3
  • GGTL5
  • D20S101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
pathway
0.69
histone modification site profile
0.62
transcription factor binding site profile
0.57
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.5   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.5   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
NAALAD2
Tchem
Family:  Enzyme
Novelty:  0.18444329
p_int:  0.999473841
p_ni:  0.000036213
p_wrong:  0.000489947
Score:  0.205
Data Source:  BioPlex,STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.997494135
p_ni:  0.002505865
Data Source:  BioPlex
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.997107927
p_ni:  0.000698382
p_wrong:  0.002193692
Score:  0.159
Data Source:  BioPlex,STRINGDB
ST6GALNAC3
Tbio
Family:  Enzyme
Novelty:  0.09030057
p_int:  0.995332093
p_ni:  0.004667907
Data Source:  BioPlex
ALG12
Tbio
Family:  Enzyme
Novelty:  0.03785588
p_int:  0.991826762
p_ni:  0.006622988
p_wrong:  0.001550251
Score:  0.169
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.987244096
p_ni:  0.012755904
Score:  0.159
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.98439669
p_ni:  0.014012356
p_wrong:  0.001590954
Score:  0.16
Data Source:  BioPlex,STRINGDB
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
p_int:  0.974421375
p_ni:  0.025578625
Score:  0.16
Data Source:  BioPlex,STRINGDB
POMT1
Tbio
Family:  Enzyme
Novelty:  0.01971429
p_int:  0.966890341
p_ni:  0.033109659
Data Source:  BioPlex
FAM69A
Tdark
Novelty:  0.35978059
p_int:  0.93596402
p_ni:  0.06403598
Data Source:  BioPlex
Pathways (12)
Aflatoxin activation and detoxification (R-HSA-5423646)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
8
97.9
glomerular filtration rate
3
2
2
8.6
92.4
BMI-adjusted hip circumference
3
6
7
88.8
suntan
1
1
1
88.4
electrocardiography
1
1
41
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
8
97.9
glomerular filtration rate
2
8.6
92.4
BMI-adjusted hip circumference
7
88.8
suntan
1
88.4
electrocardiography
41
75.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyltransferase 7
VGNC:14135
458194
Macaque
gamma-glutamyltransferase 7
706813
Mouse
MGI:1913385
207182
Rat
RGD:619870
156275
Dog
gamma-glutamyltransferase 7
VGNC:41203
485847
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyltransferase 7
Macaque
gamma-glutamyltransferase 7
Mouse
Rat
Dog
gamma-glutamyltransferase 7
Publication Statistics
PubMed Score 71.50
PubMed score by year
PubTator Score 9.17
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title