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Tbio
GGT6
Glutathione hydrolase 6

Protein Summary
Description
Cleaves glutathione conjugates. GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301395
  • ENSP00000301395
  • ENSG00000167741
  • ENST00000574154
  • ENSP00000458307
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.69
virus perturbation
0.55
tissue
0.48
tissue sample
0.48
biological process
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.952
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.949
Data Source:  STRINGDB
OPLAH
Tbio
Family:  Enzyme
Novelty:  0.03527462
Score:  0.937
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.933
Data Source:  STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.928
Data Source:  STRINGDB
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.925
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.914
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.913
Data Source:  STRINGDB
CSAD
Tbio
Family:  Enzyme
Novelty:  0.01293688
Score:  0.911
Data Source:  STRINGDB
GPX4
Tbio
Family:  Enzyme
Novelty:  0.00188213
Score:  0.911
Data Source:  STRINGDB
Pathways (12)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
2
6
7
98.9
eosinophil count
3
5
8
98.8
sum of eosinophil and basophil counts
1
3
3
93
eosinophil percentage of granulocytes
1
2
2
86.2
neutrophil percentage of granulocytes
1
2
2
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
7
98.9
eosinophil count
8
98.8
sum of eosinophil and basophil counts
3
93
eosinophil percentage of granulocytes
2
86.2
neutrophil percentage of granulocytes
2
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918772
71522
Rat
RGD:1303335
408206
Dog
gamma-glutamyltransferase 6
VGNC:41202
606867
Horse
gamma-glutamyltransferase 6
VGNC:18329
100060762
Cow
gamma-glutamyltransferase 6
VGNC:29345
613919
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gamma-glutamyltransferase 6
Horse
gamma-glutamyltransferase 6
Cow
gamma-glutamyltransferase 6
Publication Statistics
PubMed Score 58.36
PubMed score by year
PubTator Score 1.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title