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Tbio
GGT5
Glutathione hydrolase 5 proenzyme

Protein Summary
Description
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263112
  • ENSP00000263112
  • ENSG00000099998
  • ENST00000327365
  • ENSP00000330080
  • ENST00000398292
  • ENSP00000381340

Symbol
  • GGTLA1
  • GGL
  • GGT 5
  • GGTLA1
  • GGT-REL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.57
tissue sample
0.57
cell line
0.56
disease perturbation
0.56
gene perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
MVK
Tchem
Family:  Kinase
Novelty:  0.00328607
p_int:  0.99999633
p_ni:  0.00000367
Score:  0.343
Data Source:  BioPlex,STRINGDB
SLC20A2
Tbio
Family:  Transporter
Novelty:  0.00387767
p_int:  0.977693703
p_ni:  0.006732555
p_wrong:  0.015573742
Score:  0.227
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.965099614
p_ni:  0.034900385
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
SLC1A4
Tbio
Family:  Transporter
Novelty:  0.01334316
p_int:  0.827067353
p_ni:  0.172932646
Score:  0.557
Data Source:  BioPlex,STRINGDB
OPLAH
Tbio
Family:  Enzyme
Novelty:  0.03527462
Score:  0.947
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.946
Data Source:  STRINGDB
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
Score:  0.945
Data Source:  STRINGDB
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.944
Data Source:  STRINGDB
LAP3
Tchem
Family:  Enzyme
Novelty:  0.00327467
Score:  0.933
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.928
Data Source:  STRINGDB
Pathways (28)
Aflatoxin activation and detoxification (R-HSA-5423646)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Fatty acid metabolism
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Arachidonic acid metabolism
Biological oxidations
Fatty acid metabolism
Glutathione conjugation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
9
9
98.1
monocyte count
2
2
2
93.4
lymphocyte count
2
2
2
83.9
eosinophil count
3
1
3
81.1
myeloid white cell count
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
9
98.1
monocyte count
2
93.4
lymphocyte count
2
83.9
eosinophil count
3
81.1
myeloid white cell count
1
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyltransferase 5
VGNC:7340
458711
Mouse
MGI:1346063
23887
Horse
gamma-glutamyltransferase 5
VGNC:18328
100050259
Cow
gamma-glutamyltransferase 5
VGNC:29344
787326
Pig
gamma-glutamyltransferase 5
100157523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamyltransferase 5
Mouse
Horse
gamma-glutamyltransferase 5
Cow
gamma-glutamyltransferase 5
Pig
gamma-glutamyltransferase 5
Publication Statistics
PubMed Score 169.34
PubMed score by year
PubTator Score 8.04
PubTator score by year
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Related Publications
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PMID
Year
Title