Tbio GGT5 Glutathione hydrolase 5 proenzyme

Protein Summary

Description

Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P36269
• Q53XM9
• Q6GMP0
• Q96FC1
• Q9UFM5

Gene Name

• GGT5

Ensembl ID

• ENST00000263112
• ENSP00000263112
• ENSG00000099998
• ENST00000327365
• ENSP00000330080
• ENST00000398292
• ENSP00000381340

Symbol

• GGTLA1
• GGL
• GGT 5
• GGTLA1
• GGT-REL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.57
tissue sample	0.57
cell line	0.56
disease perturbation	0.56
gene perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Glutathione Hydrolase 5 Proenzyme

Protein / Hydrolase / Protease / Glutathione Hydrolase 5 Proenzyme

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Glutathione Hydrolase 5 Proenzyme

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.56   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0