Tchem GGH Gamma-glutamyl hydrolase

Protein Summary

Description

Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92820

Gene Name

• GGH

Ensembl ID

• ENST00000260118
• ENSP00000260118
• ENSG00000137563

Symbol

• GH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.86
kinase perturbation	0.81
cell line	0.72
cellular component	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Gamma-glutamyl Hydrolase

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Gamma-glutamyl Hydrolase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.68   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 304   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.68   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0