Protein Summary
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
- ENST00000260118
- ENSP00000260118
- ENSG00000137563
- GH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
histone modification site profile | 0.86 | ||
kinase perturbation | 0.81 | ||
cell line | 0.72 | ||
cellular component | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 274.68 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 304 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 274.68 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 304 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (263)
UGDH
Family: Enzyme
Novelty: 0.00284931
p_int: 0.997556479
p_ni: 0.002443521
Score: 0.674
Data Source: BioPlex,STRINGDB
ITGAV
Novelty: 0.00148589
p_int: 0.916876514
p_ni: 0.083123486
Score: 0.173
Data Source: BioPlex,STRINGDB
MKLN1
Novelty: 0.05014385
p_int: 0.868372767
p_ni: 0.131627233
Score: 0.183
Data Source: BioPlex,STRINGDB
MICA
Novelty: 0.03965901
p_int: 0.868231413
p_ni: 0.131765635
p_wrong: 0.000002952
Data Source: BioPlex
TXNDC16
Novelty: 0.25365147
p_int: 0.836070585
p_ni: 0.163929161
p_wrong: 2.54e-7
Score: 0.567
Data Source: BioPlex,STRINGDB
OS9
Novelty: 0.01490339
p_int: 0.811579182
p_ni: 0.188420818
Score: 0.417
Data Source: BioPlex,STRINGDB
CERCAM
Family: Enzyme
Novelty: 0.33392502
p_int: 0.780194288
p_ni: 0.219805623
p_wrong: 8.9e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (14)
Reactome (3)
KEGG (2)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (10)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood protein measurement | 1 | 2 | 2 | 81.6 | |||||
calcium measurement | 2 | 1 | 2 | 53.8 | |||||
age at onset | 1 | 1 | 0 | 5.8 | 36.2 | ||||
Alzheimer disease | 1 | 1 | 0 | 5.8 | 36.2 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood protein measurement | 2 | 81.6 | |||||
calcium measurement | 2 | 53.8 | |||||
age at onset | 0 | 5.8 | 36.2 | ||||
Alzheimer disease | 0 | 5.8 | 36.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gamma-glutamyl hydrolase | VGNC:6676 | 464204 | |||||
Mouse | MGI:1329035 | 14590 | ||||||
Rat | RGD:2682 | 25455 | ||||||
Dog | gamma-glutamyl hydrolase | VGNC:41198 | 100856436 | |||||
Horse | gamma-glutamyl hydrolase | VGNC:18325 | 100052567 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | gamma-glutamyl hydrolase | |||||
Mouse | ||||||
Rat | ||||||
Dog | gamma-glutamyl hydrolase | |||||
Horse | gamma-glutamyl hydrolase | |||||
Publication Statistics
PubMed Score 274.68
PubMed score by year
PubTator Score 115.30
PubTator score by year
Related Publications
Text Mined References (66)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
|---|