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Tchem
GGCT
Gamma-glutamylcyclotransferase

Protein Summary
Description
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005374
  • ENSP00000005374
  • ENSG00000006625
  • ENST00000275428
  • ENSP00000275428
  • ENST00000409144
  • ENSP00000386610
  • ENST00000409390
  • ENSP00000387235

Symbol
  • C7orf24
  • CRF21
  • GGC
  • GCTG
  • CRF21
  • C7orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
virus perturbation
0.85
transcription factor perturbation
0.8
transcription factor binding site profile
0.78
histone modification site profile
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.17   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.17   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (88)
OPLAH
Tbio
Family:  Enzyme
Novelty:  0.03527462
Score:  0.992
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.984
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.915
Data Source:  STRINGDB
GCLC
Tchem
Family:  Enzyme
Novelty:  0.00217206
Score:  0.914
Data Source:  STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
Score:  0.909
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.906
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.906
Data Source:  STRINGDB
GGACT
Tbio
Family:  Enzyme
Novelty:  0.20580326
Score:  0.905
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.904
Data Source:  STRINGDB
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.902
Data Source:  STRINGDB
Pathways (13)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
1
1
75.4
mean corpuscular volume
1
1
1
70.2
reticulocyte count
2
1
2
65.9
reticulocyte measurement
2
1
2
62.6
mean reticulocyte volume
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ferritin measurement
1
75.4
mean corpuscular volume
1
70.2
reticulocyte count
2
65.9
reticulocyte measurement
2
62.6
mean reticulocyte volume
1
35
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamylcyclotransferase
VGNC:14016
463327
Macaque
gamma-glutamylcyclotransferase
695547
Mouse
MGI:95700
110175
Rat
RGD:1304876
362368
Dog
gamma-glutamylcyclotransferase
611603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-glutamylcyclotransferase
Macaque
gamma-glutamylcyclotransferase
Mouse
Rat
Dog
gamma-glutamylcyclotransferase
Publication Statistics
PubMed Score 91.17
PubMed score by year
PubTator Score 151.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title