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Tbio
GGA2
ADP-ribosylation factor-binding protein GGA2

Protein Summary
Description
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:10747088). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15615712). This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family mem ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309859
  • ENSP00000311962
  • ENSG00000103365

Symbol
  • KIAA1080
  • VEAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
protein domain
0.92
virus perturbation
0.92
kinase perturbation
0.81
transcription factor binding site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.16   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.16   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999986929
p_ni:  0.000013071
Score:  0.879
Data Source:  BioPlex,STRINGDB
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.996114963
p_ni:  0.003885034
p_wrong:  3e-9
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
CLINT1
Tbio
Novelty:  0.00945381
p_int:  0.994295272
p_ni:  0.005704728
Score:  0.643
Data Source:  BioPlex,STRINGDB
IGF2R
Tchem
Novelty:  0.00138374
Score:  0.964
Data Source:  STRINGDB
BACE1
Tchem
Family:  Enzyme
Novelty:  0.00042175
Score:  0.958
Data Source:  Reactome,STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
Score:  0.939
Data Source:  Reactome,STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.93
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.923
Data Source:  Reactome,STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
Score:  0.912
Data Source:  Reactome,STRINGDB
RAB5B
Tbio
Family:  Enzyme
Novelty:  0.02653775
Score:  0.902
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Membrane Trafficking
Metabolism of proteins
Rab regulation of trafficking
TBC/RABGAPs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
golgi associated, gamma adaptin ear containing, ARF binding protein 2
VGNC:9078
744307
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 2
700421
Mouse
MGI:1921355
74105
Rat
RGD:1304800
293455
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 2
VGNC:41194
608555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
golgi associated, gamma adaptin ear containing, ARF binding protein 2
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 2
Mouse
Rat
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 2
Publication Statistics
PubMed Score 53.16
PubMed score by year
PubTator Score 30.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title