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Tbio
GGA1
ADP-ribosylation factor-binding protein GGA1

Protein Summary
Description
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712). This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325180
  • ENSP00000321288
  • ENSG00000100083
  • ENST00000343632
  • ENSP00000341344
  • ENST00000381756
  • ENSP00000371175
  • ENST00000406772
  • ENSP00000385287
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.9
kinase perturbation
0.88
disease perturbation
0.79
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.09   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.09   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
CEP72
Tbio
Novelty:  0.06830459
p_int:  0.999999997
p_ni:  3e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999999925
p_ni:  7.5e-8
Score:  0.571
Data Source:  BioPlex,STRINGDB
E2F5
Tbio
Family:  TF
Novelty:  0.00674159
p_int:  0.999999526
p_ni:  1e-8
p_wrong:  4.65e-7
Score:  0.239
Data Source:  BioPlex,STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
p_int:  0.999995225
p_ni:  0.000004666
p_wrong:  1.09e-7
Data Source:  BioPlex
CEP44
Tdark
Novelty:  1.20621472
p_int:  0.999994469
p_ni:  0.000005531
Data Source:  BioPlex
GGA2
Tbio
Novelty:  0.01750948
p_int:  0.999986929
p_ni:  0.000013071
Score:  0.879
Data Source:  BioPlex,STRINGDB
CCDC91
Tbio
Novelty:  0.11171935
p_int:  0.999973895
p_ni:  0.000026101
p_wrong:  5e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.999487099
p_ni:  0.000512901
Score:  0.279
Data Source:  BioPlex,STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.999321862
p_ni:  0.00067786
p_wrong:  2.78e-7
Data Source:  BioPlex
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.998969265
p_ni:  0.001030735
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Membrane Trafficking
Metabolism of proteins
Rab regulation of trafficking
TBC/RABGAPs
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
3
3
88.7
cup-to-disc ratio measurement
3
3
4
88.4
optic disc area measurement
3
3
5
81.4
age-related hearing impairment
2
1
1
1.1
52.7
serum albumin measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
3
88.7
cup-to-disc ratio measurement
4
88.4
optic disc area measurement
5
81.4
age-related hearing impairment
1
1.1
52.7
serum albumin measurement
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 1
697929
Mouse
MGI:2146207
106039
Rat
RGD:1307770
300066
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 1
VGNC:41193
481266
Horse
golgi associated, gamma adaptin ear containing, ARF binding protein 1
VGNC:18320
100147078
Species
Name
OMA
EggNOG
Inparanoid
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 1
Mouse
Rat
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 1
Horse
golgi associated, gamma adaptin ear containing, ARF binding protein 1
Publication Statistics
PubMed Score 120.09
PubMed score by year
PubTator Score 43.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title