You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Protein Summary
Description
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357308
  • ENSP00000349860
  • ENSG00000198380
  • ENST00000361060
  • ENSP00000354347

Symbol
  • GFAT
  • GFPT
  • GFA
  • GFAT
  • GFPT
  • MSLG
  • CMS12
  • GFAT1
  • CMSTA1
  • GFAT 1
  • GFAT1m
  • GFPT1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
biological process
0.98
interacting protein
0.93
kinase perturbation
0.93
ligand (protein) perturbation
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.04   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 345.04   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0