Tbio GFM2 Ribosome-releasing factor 2, mitochondrial

Protein Summary

Description

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q969S9
• A0AR28
• Q8N6D8
• Q8WYI0
• Q9H6Z1
• RRF2mt

Gene Name

• GFM2

Ensembl ID

• ENST00000296805
• ENSP00000296805
• ENSG00000164347
• ENST00000345239
• ENSP00000296804
• ENST00000427854
• ENSP00000405808
• ENST00000509430
• ENSP00000427004

Symbol

• EFG2
• EFG2
• RRF2
• MRRF2
• hEFG2
• MST027
• RRF2mt
• EF-G2mt
• MSTP027
• mEF-G 2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.96
transcription factor perturbation	0.91
transcription factor binding site profile	0.83
histone modification site profile	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Ribosome-releasing Factor 2, Mitochondrial

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Ribosome-releasing Factor 2, Mitochondrial

Protein / Hydrolase / Ribosome-releasing Factor 2, Mitochondrial

Protein / Enzyme Modulator / G-protein / Ribosome-releasing Factor 2, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Ribosome-releasing Factor 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.62   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0