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Tbio
GFM2
Ribosome-releasing factor 2, mitochondrial

Protein Summary
Description
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296805
  • ENSP00000296805
  • ENSG00000164347
  • ENST00000345239
  • ENSP00000296804
  • ENST00000427854
  • ENSP00000405808
  • ENST00000509430
  • ENSP00000427004

Symbol
  • EFG2
  • EFG2
  • RRF2
  • MRRF2
  • hEFG2
  • MST027
  • RRF2mt
  • EF-G2mt
  • MSTP027
  • mEF-G 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
transcription factor perturbation
0.91
transcription factor binding site profile
0.83
histone modification site profile
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.97   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999887262
p_ni:  0.000112736
p_wrong:  2e-9
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.999434314
p_ni:  0.000483257
p_wrong:  0.000082429
Data Source:  BioPlex
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.998787891
p_ni:  0.001209264
p_wrong:  0.000002845
Data Source:  BioPlex
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.998019896
p_ni:  0.001962729
p_wrong:  0.000017375
Score:  0.25
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.997144565
p_ni:  0.002849821
p_wrong:  0.000005615
Score:  0.266
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.996236307
p_ni:  0.003749174
p_wrong:  0.000014519
Score:  0.972
Data Source:  BioPlex,STRINGDB
TUFM
Tchem
Novelty:  0.03251632
p_int:  0.99578213
p_ni:  0.004210935
p_wrong:  0.000006936
Score:  0.566
Data Source:  BioPlex,STRINGDB
RARS2
Tbio
Family:  Enzyme
Novelty:  0.01185296
p_int:  0.991584967
p_ni:  0.002053795
p_wrong:  0.006361238
Score:  0.475
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.929367693
p_ni:  0.061539143
p_wrong:  0.009093164
Data Source:  BioPlex
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.908583782
p_ni:  0.091416218
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation termination
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation termination
Translation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G elongation factor mitochondrial 2
VGNC:4010
471518
Macaque
G elongation factor mitochondrial 2
704247
Mouse
MGI:2444783
320806
Rat
RGD:1309854
294672
Dog
G elongation factor mitochondrial 2
VGNC:41184
478101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G elongation factor mitochondrial 2
Macaque
G elongation factor mitochondrial 2
Mouse
Rat
Dog
G elongation factor mitochondrial 2
Publication Statistics
PubMed Score 37.97
PubMed score by year
PubTator Score 12.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title