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Tbio
GFI1B
Zinc finger protein Gfi-1b

Protein Summary
Description
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339463
  • ENSP00000344782
  • ENSG00000165702
  • ENST00000372122
  • ENSP00000361195
  • ENST00000372123
  • ENSP00000361196

Symbol
  • BDPLT17
  • ZNF163B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
transcription factor binding site profile
0.68
biological process
0.67
cell line
0.64
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.68   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.68   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
Score:  0.859
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.848
Data Source:  STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.739
Data Source:  STRINGDB
MEGF8
Tbio
Novelty:  0.24616449
Score:  0.732
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.726
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.724
Data Source:  STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
Score:  0.711
Data Source:  STRINGDB
LYL1
Tbio
Family:  TF
Novelty:  0.02669155
Score:  0.707
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.688
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
9
13
98.4
mean platelet volume
4
4
6
98.4
platelet count
3
4
5
98.1
eosinophil percentage of leukocytes
2
7
10
97.4
red blood cell distribution width
3
4
6
97.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
13
98.4
mean platelet volume
6
98.4
platelet count
5
98.1
eosinophil percentage of leukocytes
10
97.4
red blood cell distribution width
6
97.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth factor independent 1B transcriptional repressor
VGNC:13890
473080
Macaque
growth factor independent 1B transcriptional repressor
714593
Mouse
MGI:1276578
14582
Rat
RGD:1311727
311832
Dog
growth factor independent 1B transcriptional repressor
VGNC:41182
491281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth factor independent 1B transcriptional repressor
Macaque
growth factor independent 1B transcriptional repressor
Mouse
Rat
Dog
growth factor independent 1B transcriptional repressor
Publication Statistics
PubMed Score 72.68
PubMed score by year
PubTator Score 45.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text