GFAP
Glial fibrillary acidic protein
Protein Summary
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
- ENST00000435360
- ENSP00000403962
- ENSG00000131095
- ENST00000588735
- ENSP00000466598
- ENST00000638281
- ENSP00000491088
- ALXDRD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.99 | ||
gene perturbation | 0.99 | ||
interacting protein | 0.99 | ||
hub protein | 0.98 | ||
kinase | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5202.7 (req: < 5)
Gene RIFs: 256 (req: <= 3)
Antibodies: 2703 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5202.7 (req: >= 5)
Gene RIFs: 256 (req: > 3)
Antibodies: 2703 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0