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Tbio
GEN1
Flap endonuclease GEN homolog 1

Protein Summary
Description
Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation (PubMed:19020614, PubMed:26682650). Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of the first strand is rate limiting, while second strand cleavage is rapid. Largely monomeric, dimerizes on the HJ and the first nick occurs upon dimerization at the junction (PubMed:26578604). Efficiently cleaves both single and double HJs contained within large recombination intermediates. Exhibits a weak sequence preference for incision between two G residues that reside in a T-rich region of DNA (PubM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317402
  • ENSP00000318977
  • ENSG00000178295
  • ENST00000381254
  • ENSP00000370653

Symbol
  • Gen
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor
0.78
cell type or tissue
0.74
protein domain
0.73
molecular function
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.25   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.25   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.999840199
p_ni:  2.6e-8
p_wrong:  0.000159775
Data Source:  BioPlex
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
Score:  0.986
Data Source:  STRINGDB
XRCC3
Tbio
Novelty:  0.00266163
Score:  0.98
Data Source:  Reactome,STRINGDB
RMI2
Tbio
Novelty:  0.02516878
Score:  0.979
Data Source:  STRINGDB
RMI1
Tbio
Novelty:  0.01222442
Score:  0.975
Data Source:  STRINGDB
WRN
Tbio
Family:  Enzyme
Novelty:  0.00163164
Score:  0.974
Data Source:  STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.974
Data Source:  STRINGDB
TOP3A
Tbio
Family:  Enzyme
Novelty:  0.0055546
Score:  0.973
Data Source:  STRINGDB
RAD51C
Tbio
Novelty:  0.0063568
Score:  0.973
Data Source:  Reactome,STRINGDB
MRE11
Tbio
Novelty:  0.01038348
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
DNA Double-Strand Break Repair (R-HSA-5693532)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homology Directed Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
30.2
blood protein measurement
1
1
1
9.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
30.2
blood protein measurement
1
9.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GEN1, Holliday junction 5' flap endonuclease
VGNC:271
470313
Macaque
GEN1, Holliday junction 5' flap endonuclease
699692
Mouse
MGI:2443149
209334
Rat
RGD:1559792
298884
Dog
GEN1, Holliday junction 5' flap endonuclease
VGNC:41179
482980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GEN1, Holliday junction 5' flap endonuclease
Macaque
GEN1, Holliday junction 5' flap endonuclease
Mouse
Rat
Dog
GEN1, Holliday junction 5' flap endonuclease
Publication Statistics
PubMed Score 253.25
PubMed score by year
PubTator Score 83.61
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title