Tbio GEMIN7 Gem-associated protein 7

Protein Summary

Description

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H840
• Q6IA34
• Gemin-7

Gene Name

• GEMIN7

Ensembl ID

• ENST00000270257
• ENSP00000270257
• ENSG00000142252
• ENST00000391951
• ENSP00000375813
• ENST00000591607
• ENSP00000466342
• ENST00000591747
• ENSP00000465704

Symbol

• SIP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
drug perturbation	0.87
transcription factor	0.83
transcription factor binding site profile	0.81
histone modification site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

GEMIN8

Tbio

Novelty:  0.19515325

p_int:  0.999999736

p_ni:  2.63e-7

p_wrong:  2e-9

Score:  0.996

Data Source:  BioPlex,STRINGDB

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.999996624

p_ni:  0.000003368

p_wrong:  8e-9

Score:  0.611

Data Source:  BioPlex,STRINGDB

GEMIN5

Tbio

Novelty:  0.03683801

p_int:  0.999991422

p_ni:  0.000008578

Score:  0.985

Data Source:  BioPlex,STRINGDB

GEMIN6

Tbio

Novelty:  0.02104816

p_int:  0.999989011

p_ni:  0.000010989

Score:  0.999

Data Source:  BioPlex,STRINGDB

GEMIN4

Tbio

Novelty:  0.03731756

p_int:  0.999725083

p_ni:  0.000274917

Score:  0.986

Data Source:  BioPlex,STRINGDB

DDX20

Tbio

Family:  Enzyme

Novelty:  0.01854078

p_int:  0.996967409

p_ni:  0.000673528

p_wrong:  0.002359064

Score:  0.995

Data Source:  BioPlex,STRINGDB

DUSP14

Tbio

Family:  Enzyme

Novelty:  0.04013065

p_int:  0.994006442

p_ni:  0.005993557

p_wrong:  1e-9

Data Source:  BioPlex

STRAP

Tbio

Family:  Enzyme

Novelty:  0.0336013

p_int:  0.991963507

p_ni:  0.008036244

p_wrong:  2.49e-7

Score:  0.996

Data Source:  BioPlex,STRINGDB

GEMIN2

Tbio

Novelty:  0.02072868

p_int:  0.966781541

p_ni:  0.003094455

p_wrong:  0.030124005

Score:  0.997

Data Source:  BioPlex,STRINGDB

LRRC15

Tbio

Novelty:  0.03701624

p_int:  0.929187885

p_ni:  0.070812115

p_wrong:  1e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Metabolism of non-coding RNA	53 targets	R-HSA-194441
Reactome	snRNP Assembly	53 targets	R-HSA-191859

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Metabolism of non-coding RNA	53 targets	R-HSA-194441
snRNP Assembly	53 targets	R-HSA-191859

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (8)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
cytosol	Inferred from Direct Assay (IDA)	UniProtKB
Gemini of coiled bodies	Inferred from Direct Assay (IDA)	UniProtKB
nuclear body	Inferred from Direct Assay (IDA)	UniProtKB
nucleoplasm	Inferred from Direct Assay (IDA)	UniProtKB
nucleus	Inferred from Direct Assay (IDA)	HPA
SMN complex	Inferred from Direct Assay (IDA)	UniProtKB
SMN-Sm protein complex	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	1	14	14		97.9
Alzheimer's disease	EFO_0000249	2	13	0	7.6	97.4
family history of Alzheimer’s disease	EFO_0009268	1	11	0	7.9	97.3
low density lipoprotein cholesterol measurement	EFO_0004611	2	13	13		94.8
C-reactive protein measurement	EFO_0004458	2	6	6		92.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
apolipoprotein B measurement	EFO_0004615	14		97.9
Alzheimer's disease	EFO_0000249	0	7.6	97.4
family history of Alzheimer’s disease	EFO_0009268	0	7.9	97.3
low density lipoprotein cholesterol measurement	EFO_0004611	13		94.8
C-reactive protein measurement	EFO_0004458	6		92.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
Alzheimer's disease
apolipoprotein B measurement
beta-amyloid 1-42 measurement
C-reactive protein measurement
family history of Alzheimer’s disease
high density lipoprotein cholesterol measurement
low density lipoprotein cholesterol measurement
red blood cell distribution width
sleep duration

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	gem nuclear organelle associated protein 7	MGI:1916981	69731
Rat	gem (nuclear organelle) associated protein 7	RGD:1597035	499391
Dog	gem nuclear organelle associated protein 7	VGNC:41177	100855650
Horse	gem nuclear organelle associated protein 7	VGNC:18306	100065597
Cow	gem nuclear organelle associated protein 7	VGNC:29320	618024

Species	Name	OMA	EggNOG	Inparanoid
Mouse	gem nuclear organelle associated protein 7
Rat	gem (nuclear organelle) associated protein 7
Dog	gem nuclear organelle associated protein 7
Horse	gem nuclear organelle associated protein 7
Cow	gem nuclear organelle associated protein 7

Publication Statistics

PubMed Score 17.89

PubMed score by year

Reset Zoom

PubTator Score 12.31

PubTator score by year

Reset Zoom

Related Publications

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Text