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Tbio
GEMIN4
Gem-associated protein 4

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319004
  • ENSP00000321706
  • ENSG00000179409

Symbol
  • p97
  • HC56
  • HCAP1
  • HHRF-1
  • NEDMCR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
drug perturbation
0.87
cellular component
0.85
interacting protein
0.82
histone modification site profile
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.17   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.17   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.999861476
p_ni:  0.000138524
Score:  0.731
Data Source:  BioPlex,STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
p_int:  0.999789508
p_ni:  0.000210492
Score:  0.998
Data Source:  BioPlex,STRINGDB
GEMIN7
Tbio
Novelty:  0.04835353
p_int:  0.999725083
p_ni:  0.000274917
Score:  0.986
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.994031487
p_ni:  0.005968513
Score:  0.96
Data Source:  BioPlex,STRINGDB
GEMIN6
Tbio
Novelty:  0.02104816
p_int:  0.989759863
p_ni:  0.010240137
Score:  0.998
Data Source:  BioPlex,STRINGDB
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.985844717
p_ni:  0.014155283
Score:  0.992
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.979522631
p_ni:  0.020477369
Score:  0.942
Data Source:  BioPlex,STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.976192561
p_ni:  0.023807439
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.967833742
p_ni:  0.032166258
Data Source:  BioPlex
GEMIN2
Tbio
Novelty:  0.02072868
p_int:  0.962655142
p_ni:  0.037344858
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
7
7
93.1
BMI-adjusted hip circumference
1
7
7
92.1
heel bone mineral density
2
2
2
83.4
4
1
0
1.1
76.1
platelet crit
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
7
93.1
BMI-adjusted hip circumference
7
92.1
heel bone mineral density
2
83.4
0
1.1
76.1
platelet crit
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 4
VGNC:12155
454403
Macaque
gem nuclear organelle associated protein 4
699841
Mouse
MGI:2449313
276919
Rat
RGD:1563715
497958
Dog
gem nuclear organelle associated protein 4
VGNC:41174
611189
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gem nuclear organelle associated protein 4
Macaque
gem nuclear organelle associated protein 4
Mouse
Rat
Dog
gem nuclear organelle associated protein 4
Publication Statistics
PubMed Score 25.17
PubMed score by year
PubTator Score 27.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title