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Tbio
GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

Protein Summary
Description
Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336898
  • ENSP00000337972
  • ENSG00000158555
  • ENST00000526177
  • ENSP00000434050
  • ENST00000529721
  • ENSP00000433214
  • ENST00000533784
  • ENSP00000437049
  • ENST00000533805
  • ENSP00000435196

Symbol
  • GDE2
  • GDE2
  • PP1665
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
histone modification site profile
0.8
PubMedID
0.73
transcription factor
0.65
tissue sample
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.23   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.23   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0