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Tbio
GDPD1
Lysophospholipase D GDPD1

Protein Summary
Description
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. This gene encodes a member of the glycerophosphodiester phosphodiesterase family of enzymes that catalyze the hydrolysis of deacylated glycerophospholipids to glycerol phosphate and alcohol. The encoded protein is localized to the cytoplasm and concentrates near the perinuclear region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284116
  • ENSP00000284116
  • ENSG00000153982
  • ENST00000581140
  • ENSP00000463273
  • ENST00000581276
  • ENSP00000464690

Symbol
  • GDE4
  • GDE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
transcription factor binding site profile
0.74
tissue sample
0.68
transcription factor
0.65
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
APOA1
Tbio
Novelty:  0.0001216
p_int:  0.999999931
p_ni:  6.9e-8
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.99999959
p_ni:  4.1e-7
Data Source:  BioPlex
CP
Tbio
Novelty:  0.00103285
p_int:  0.999999243
p_ni:  5.41e-7
p_wrong:  2.16e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
C3
Tclin
Novelty:  0.00019115
p_int:  0.999997541
p_ni:  0.000002459
Data Source:  BioPlex
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.999996684
p_ni:  4.23e-7
p_wrong:  0.000002893
Data Source:  BioPlex
HP
Tbio
Novelty:  0.00016649
p_int:  0.999996156
p_ni:  0.000003834
p_wrong:  1e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
HBA1
Tclin
Novelty:  0.00094113
p_int:  0.999963934
p_ni:  0.000036066
Data Source:  BioPlex
A1BG
Tbio
Novelty:  0.00508743
p_int:  0.999950657
p_ni:  2.55e-7
p_wrong:  0.000049088
Score:  0.219
Data Source:  BioPlex,STRINGDB
ORM1
Tbio
Novelty:  0.007451
p_int:  0.999943914
p_ni:  0.000056086
Score:  0.51
Data Source:  BioPlex,STRINGDB
HPX
Tbio
Novelty:  0.00138137
p_int:  0.999934391
p_ni:  0.000017198
p_wrong:  0.000048411
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
68.6
myeloperoxidase measurement
1
1
1
53.7
platelet count
1
1
1
11
HbA1c measurement
1
1
1
7.1
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
68.6
myeloperoxidase measurement
1
53.7
platelet count
1
11
HbA1c measurement
1
7.1
1
2.9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerophosphodiester phosphodiesterase domain containing 1
VGNC:12145
455166
Mouse
MGI:1913819
66569
Rat
RGD:1311813
303407
Dog
glycerophosphodiester phosphodiesterase domain containing 1
VGNC:49766
491117
Horse
glycerophosphodiester phosphodiesterase domain containing 1
VGNC:18296
100057236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerophosphodiester phosphodiesterase domain containing 1
Mouse
Rat
Dog
glycerophosphodiester phosphodiesterase domain containing 1
Horse
glycerophosphodiester phosphodiesterase domain containing 1
Publication Statistics
PubMed Score 5.71
PubMed score by year
PubTator Score 2.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title