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Tbio
GDNF
Glial cell line-derived neurotrophic factor

Protein Summary
Description
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326524
  • ENSP00000317145
  • ENSG00000168621
  • ENST00000344622
  • ENSP00000339703
  • ENST00000381826
  • ENSP00000371248
  • ENST00000427982
  • ENSP00000409007
  • ENST00000515058
  • ENSP00000425928
  • ENST00000620847
  • ENSP00000478722

Symbol
  • ATF
  • ATF1
  • ATF2
  • HSCR3
  • HFB1-GDNF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.92
gene perturbation
0.83
disease
0.74
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3111.9   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3111.9   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (246)
GID4
Tbio
Novelty:  0.05252674
p_int:  0.966132582
p_ni:  0.033867418
Score:  0.541
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.89200825
p_ni:  0.10799175
Score:  0.547
Data Source:  BioPlex,STRINGDB
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.7576403
p_ni:  0.2423597
Score:  0.607
Data Source:  BioPlex,STRINGDB
RET
Tclin
Family:  Kinase
Novelty:  0.00028324
Score:  0.998
Data Source:  Reactome,STRINGDB
GFRA1
Tbio
Novelty:  0.00373994
Score:  0.996
Data Source:  Reactome,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.978
Data Source:  Reactome,STRINGDB
GFRA2
Tbio
Novelty:  0.06235436
Score:  0.974
Data Source:  Reactome,STRINGDB
GFRA3
Tbio
Novelty:  0.10149548
Score:  0.964
Data Source:  Reactome,STRINGDB
BDNF
Tchem
Novelty:  0.00006891
Score:  0.958
Data Source:  STRINGDB
GFRA4
Tbio
Novelty:  0.17473076
Score:  0.957
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (81)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glial cell derived neurotrophic factor
VGNC:14838
471566
Macaque
glial cell derived neurotrophic factor
706345
Mouse
MGI:107430
14573
Rat
RGD:2677
25453
Dog
glial cell derived neurotrophic factor
VGNC:41166
489224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glial cell derived neurotrophic factor
Macaque
glial cell derived neurotrophic factor
Mouse
Rat
Dog
glial cell derived neurotrophic factor
Publication Statistics
PubMed Score 3111.90
PubMed score by year
PubTator Score 1107.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text