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Tbio
GDNF
Glial cell line-derived neurotrophic factor

Protein Summary
Description
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326524
  • ENSP00000317145
  • ENSG00000168621
  • ENST00000344622
  • ENSP00000339703
  • ENST00000381826
  • ENSP00000371248
  • ENST00000427982
  • ENSP00000409007
  • ENST00000515058
  • ENSP00000425928
  • ENST00000620847
  • ENSP00000478722

Symbol
  • ATF
  • ATF1
  • ATF2
  • HSCR3
  • HFB1-GDNF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.92
gene perturbation
0.83
disease
0.74
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3341.18   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3341.18   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0