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Tbio
GDF9
Growth/differentiation factor 9

Protein Summary
Description
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378673
  • ENSP00000367942
  • ENSG00000164404

Symbol
  • POF14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
biological process
0.76
protein domain
0.73
tissue sample
0.7
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.27   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.27   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
MYH11
Tbio
Novelty:  0.00142474
p_int:  0.999937249
p_ni:  0.000029226
p_wrong:  0.000033526
Score:  0.227
Data Source:  BioPlex,STRINGDB
AP5B1
Tdark
Novelty:  0.06116142
p_int:  0.991262617
p_ni:  0.008736782
p_wrong:  6.01e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.964083595
p_ni:  0.035916405
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.945154969
p_ni:  0.054845031
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.944619245
p_ni:  0.055380755
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.944599936
p_ni:  0.055400064
Data Source:  BioPlex
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.909953902
p_ni:  0.090044691
p_wrong:  0.000001408
Score:  0.167
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.881158444
p_ni:  0.118841121
p_wrong:  4.35e-7
Data Source:  BioPlex
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.858725802
p_ni:  0.004906217
p_wrong:  0.136367981
Score:  0.263
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.851841005
p_ni:  0.14815757
p_wrong:  0.000001425
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.1
71.6
IGF-1 measurement
1
1
1
68
glomerular filtration rate
2
1
2
64.9
mosquito bite reaction itch intensity measurement
1
1
1
64
1
1
0
1.1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
71.6
IGF-1 measurement
1
68
glomerular filtration rate
2
64.9
mosquito bite reaction itch intensity measurement
1
64
0
1.1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 9
VGNC:4009
107974862
Mouse
MGI:95692
14566
Rat
RGD:71038
59304
Dog
growth differentiation factor 9
VGNC:41164
100313495
Horse
growth differentiation factor 9
VGNC:18293
100072822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 9
Mouse
Rat
Dog
growth differentiation factor 9
Horse
growth differentiation factor 9
Publication Statistics
PubMed Score 432.27
PubMed score by year
PubTator Score 130.98
PubTator score by year
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Related Publications
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PMID
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