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Tbio
GDF5
Growth/differentiation factor 5

Protein Summary
Description
Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374369
  • ENSP00000363489
  • ENSG00000125965
  • ENST00000374372
  • ENSP00000363492

Symbol
  • BMP14
  • CDMP1
  • OS5
  • LAP4
  • BDA1C
  • BMP14
  • CDMP1
  • LAP-4
  • SYM1B
  • SYNS2
  • BMP-14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.96
biological process
0.87
cell type or tissue
0.85
biological term
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.39   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.39   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0