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Tclin
GDF11
Growth/differentiation factor 11

Protein Summary
Description
Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257868
  • ENSP00000257868
  • ENSG00000135414

Symbol
  • BMP11
  • BMP11
  • BMP-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.73
protein domain
0.73
virus perturbation
0.72
phenotype
0.71
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.88   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.88   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
CRP
Tbio
Novelty:  0.00001517
p_int:  0.999332903
p_ni:  0.000667051
p_wrong:  4.5e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999304461
p_ni:  0.00069549
p_wrong:  4.9e-8
Data Source:  BioPlex
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.998430803
p_ni:  0.001569194
p_wrong:  2e-9
Data Source:  BioPlex
LIPH
Tbio
Family:  Enzyme
Novelty:  0.00961658
p_int:  0.99788528
p_ni:  0.001854985
p_wrong:  0.000259735
Score:  0.179
Data Source:  BioPlex,STRINGDB
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.996085108
p_ni:  0.003914888
p_wrong:  4e-9
Data Source:  BioPlex
BMP7
Tbio
Novelty:  0.00049424
p_int:  0.995384026
p_ni:  0.003406765
p_wrong:  0.001209209
Score:  0.334
Data Source:  BioPlex,STRINGDB
TMEM25
Tdark
Novelty:  0.35505784
p_int:  0.993939399
p_ni:  0.0059264
p_wrong:  0.0001342
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.991747257
p_ni:  0.008110988
p_wrong:  0.000141755
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.991311366
p_ni:  0.008503924
p_wrong:  0.00018471
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.990503232
p_ni:  0.009279198
p_wrong:  0.000217569
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
3
13.8
96.4
Myopia
3
2
0
1.3
93
age at onset
1
1
0
13.8
83.1
Abnormality of refraction
1
1
1
53.3
atrophic macular degeneration
1
1
0
1.2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
13.8
96.4
Myopia
0
1.3
93
age at onset
0
13.8
83.1
Abnormality of refraction
1
53.3
atrophic macular degeneration
0
1.2
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 11
VGNC:5399
451970
Macaque
growth differentiation factor 11 [Source:HGNC Symbol;Acc:HGNC:4216]
Mouse
MGI:1338027
14561
Rat
RGD:2673
29454
Dog
growth differentiation factor 11
VGNC:41159
606826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 11
Macaque
growth differentiation factor 11 [Source:HGNC Symbol;Acc:HGNC:4216]
Mouse
Rat
Dog
growth differentiation factor 11
Publication Statistics
PubMed Score 241.88
PubMed score by year
PubTator Score 60.34
PubTator score by year
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PMID
Year
Title