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Tbio
GDE1
Glycerophosphodiester phosphodiesterase 1

Protein Summary
Description
Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353258
  • ENSP00000261386
  • ENSG00000006007

Symbol
  • MIR16
  • MIR16
  • 363E6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.84
virus perturbation
0.79
microRNA
0.75
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999999826
p_ni:  1.74e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.999978897
p_ni:  0.000003035
p_wrong:  0.000018068
Data Source:  BioPlex
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.99997501
p_ni:  0.000024955
p_wrong:  3.5e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
ADCY2
Tchem
Family:  Enzyme
Novelty:  0.01649836
p_int:  0.999157181
p_ni:  0.000440346
p_wrong:  0.000402473
Score:  0.174
Data Source:  BioPlex,STRINGDB
FAM84B
Tbio
Novelty:  0.10702561
p_int:  0.999130735
p_ni:  0.000020948
p_wrong:  0.000848317
Score:  0.325
Data Source:  BioPlex,STRINGDB
APOA2
Tbio
Novelty:  0.00117627
p_int:  0.999043348
p_ni:  0.000873598
p_wrong:  0.000083054
Data Source:  BioPlex
CXorf58
Tdark
Novelty:  1.57241379
p_int:  0.979665017
p_ni:  0.01583753
p_wrong:  0.004497453
Score:  0.622
Data Source:  BioPlex,STRINGDB
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.938477508
p_ni:  0.059571663
p_wrong:  0.00195083
Score:  0.21
Data Source:  BioPlex,STRINGDB
CDK14
Tchem
Family:  Kinase
Novelty:  0.02074169
p_int:  0.934136961
p_ni:  0.056269606
p_wrong:  0.009593433
Score:  0.311
Data Source:  BioPlex,STRINGDB
DAZAP2
Tbio
Novelty:  0.02387823
p_int:  0.921578348
p_ni:  0.000022803
p_wrong:  0.078398849
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
1
0
6
44.6
Alzheimer disease
1
1
0
6
44.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
0
6
44.6
Alzheimer disease
0
6
44.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerophosphodiester phosphodiesterase 1
VGNC:5776
453968
Macaque
glycerophosphodiester phosphodiesterase 1
694849
Mouse
MGI:1891827
56209
Rat
RGD:621788
60418
Dog
glycerophosphodiester phosphodiesterase 1
479827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerophosphodiester phosphodiesterase 1
Macaque
glycerophosphodiester phosphodiesterase 1
Mouse
Rat
Dog
glycerophosphodiester phosphodiesterase 1
Publication Statistics
PubMed Score 19.39
PubMed score by year
PubTator Score 232.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title