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Tbio
GDAP1
Ganglioside-induced differentiation-associated protein 1

Protein Summary
Description
Regulates the mitochondrial network by promoting mitochondrial fission. This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220822
  • ENSP00000220822
  • ENSG00000104381
  • ENST00000434412
  • ENSP00000417006

Symbol
  • CMT4
  • CMT4A
  • CMTRIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
histone modification site profile
0.74
transcription factor perturbation
0.74
microRNA
0.71
tissue
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.08   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.08   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
MINPP1
Tbio
Family:  Enzyme
Novelty:  0.02584444
p_int:  0.91018423
p_ni:  0.08981577
Score:  0.622
Data Source:  BioPlex,STRINGDB
PMP2
Tbio
Novelty:  0.00428146
Score:  0.907
Data Source:  STRINGDB
MFN2
Tbio
Novelty:  0.00137876
Score:  0.85
Data Source:  STRINGDB
MFN1
Tbio
Novelty:  0.00372574
Score:  0.821
Data Source:  STRINGDB
SH3TC2
Tbio
Novelty:  0.0205934
Score:  0.795
Data Source:  STRINGDB
FIS1
Tbio
Novelty:  0.0033607
Score:  0.794
Data Source:  STRINGDB
MPZ
Tbio
Novelty:  0.00223212
Score:  0.767
Data Source:  STRINGDB
SBF2
Tbio
Novelty:  0.02647873
Score:  0.756
Data Source:  STRINGDB
ATCAY
Tbio
Novelty:  0.08312317
Score:  0.741
Data Source:  STRINGDB
GJB1
Tbio
Novelty:  0.00109019
Score:  0.737
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Class I peroxisomal membrane protein import (R-HSA-9603798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Class I peroxisomal membrane protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ganglioside induced differentiation associated protein 1
VGNC:12016
464239
Macaque
ganglioside induced differentiation associated protein 1
697136
Mouse
MGI:1338002
14545
Rat
RGD:1309005
312890
Dog
ganglioside induced differentiation associated protein 1
VGNC:41155
487002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ganglioside induced differentiation associated protein 1
Macaque
ganglioside induced differentiation associated protein 1
Mouse
Rat
Dog
ganglioside induced differentiation associated protein 1
Publication Statistics
PubMed Score 164.08
PubMed score by year
PubTator Score 98.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text