Protein Summary
Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000238018
- ENSP00000238018
- ENSG00000119125
- ENST00000358399
- ENSP00000351170
- ENST00000475764
- ENSP00000436619
- ENST00000545168
- ENSP00000437972
- KIAA1258
- GAH
- CYPIN
- GUANASE
- NEDASIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
small molecule perturbation | 0.73 | ||
microRNA | 0.66 | ||
cellular component | 0.57 | ||
gene perturbation | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.86 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 254 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.86 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 254 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (76)
TEFM
Novelty: 0.10836617
p_int: 0.983441665
p_ni: 0.016558312
p_wrong: 2.3e-8
Data Source: BioPlex
DTX3
Family: Enzyme
Novelty: 0.06212096
p_int: 0.918692367
p_ni: 0.081307633
Score: 0.209
Data Source: BioPlex,STRINGDB
C7orf31
Novelty: 1.72375691
p_int: 0.885050632
p_ni: 0.114949368
Score: 0.379
Data Source: BioPlex,STRINGDB
MATN3
Novelty: 0.00426202
p_int: 0.820741467
p_ni: 0.179258533
Score: 0.379
Data Source: BioPlex,STRINGDB
HERC3
Family: Enzyme
Novelty: 0.05231675
p_int: 0.764491039
p_ni: 0.235508961
Score: 0.237
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
Pathways (12)
Reactome (4)
KEGG (2)
PathwayCommons (5)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Purine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Purine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum albumin measurement | 1 | 1 | 1 | 38.8 | |||||
metabolic syndrome | 1 | 1 | 1 | 3.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum albumin measurement | 1 | 38.8 | |||||
metabolic syndrome | 1 | 3.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | guanine deaminase | VGNC:4751 | 472950 | |||||
Macaque | guanine deaminase | 701796 | ||||||
Mouse | MGI:95678 | 14544 | ||||||
Rat | RGD:621617 | 83585 | ||||||
Dog | guanine deaminase | VGNC:41154 | 484169 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | guanine deaminase | |||||
Macaque | guanine deaminase | |||||
Mouse | ||||||
Rat | ||||||
Dog | guanine deaminase | |||||
Publication Statistics
PubMed Score 62.86
PubMed score by year
PubTator Score 732.08
PubTator score by year
Related Publications
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Text |
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