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Tdark
GCSAML
Germinal center-associated signaling and motility-like protein

Protein Summary
Description
This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366488
  • ENSP00000355444
  • ENSG00000169224
  • ENST00000366489
  • ENSP00000355445
  • ENST00000366491
  • ENSP00000355447
  • ENST00000536561
  • ENSP00000446460

Symbol
  • C1orf150
  • C1orf150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
cell line
0.64
cellular component
0.64
trait
0.61
microRNA
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999999427
p_ni:  5.73e-7
Data Source:  BioPlex
ZMYM6
Tdark
Novelty:  0.4933879
p_int:  0.985098424
p_ni:  0.014901574
p_wrong:  2e-9
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.970119608
p_ni:  0.029880392
Data Source:  BioPlex
MARS2
Tbio
Family:  Enzyme
Novelty:  0.02533315
p_int:  0.968990096
p_ni:  0.030560469
p_wrong:  0.000449436
Data Source:  BioPlex
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.966100995
p_ni:  0.020144508
p_wrong:  0.013754497
Data Source:  BioPlex
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
p_int:  0.938750552
p_ni:  0.061249449
Data Source:  BioPlex
CDK5RAP1
Tbio
Novelty:  0.0347805
p_int:  0.787934608
p_ni:  0.212065392
Data Source:  BioPlex
OR2C3
Tdark
Family:  oGPCR
Novelty:  2.22090141
Score:  0.559
Data Source:  STRINGDB
OR14A2
Tdark
Family:  oGPCR
Novelty:  2.51428571
Score:  0.556
Data Source:  STRINGDB
CCDC71L
Tdark
Novelty:  1.22334925
Score:  0.539
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
14
16
99.2
platelet count
3
5
6
3.1
99
platelet crit
2
3
5
96.6
mean platelet volume
2
2
4
95.5
leukocyte count
2
3
3
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
16
99.2
platelet count
6
3.1
99
platelet crit
5
96.6
mean platelet volume
4
95.5
leukocyte count
3
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
germinal center associated signaling and motility like
708969
Dog
germinal center associated signaling and motility like
VGNC:41153
607068
Horse
germinal center associated signaling and motility like
VGNC:18282
102150663
Opossum
germinal center associated signaling and motility
103095669
Species
Name
OMA
EggNOG
Inparanoid
Macaque
germinal center associated signaling and motility like
Dog
germinal center associated signaling and motility like
Horse
germinal center associated signaling and motility like
Opossum
germinal center associated signaling and motility
Publication Statistics
PubMed Score 1.79
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title