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Tbio
GCNT4
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4

Protein Summary
Description
Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O-glycan or I-branching enzyme activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322348
  • ENSP00000317027
  • ENSG00000176928

Symbol
  • C2GNT3
  • LINC01336
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.64
cellular component
0.62
tissue sample
0.54
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.23   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.23   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.964
Data Source:  STRINGDB
MUC20
Tbio
Novelty:  0.04645313
Score:  0.955
Data Source:  STRINGDB
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
Score:  0.95
Data Source:  STRINGDB
C1GALT1C1
Tbio
Family:  Enzyme
Novelty:  0.01318017
Score:  0.941
Data Source:  STRINGDB
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
Score:  0.937
Data Source:  STRINGDB
ST3GAL2
Tbio
Family:  Enzyme
Novelty:  0.03503891
Score:  0.934
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.923
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.923
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.919
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
5
5
82
total cholesterol measurement
1
3
3
73.7
apolipoprotein B measurement
1
2
2
62.1
Alzheimer disease
1
1
0
1.2
41.9
aspartate aminotransferase measurement
1
1
0
8
16.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
82
total cholesterol measurement
3
73.7
apolipoprotein B measurement
2
62.1
Alzheimer disease
0
1.2
41.9
aspartate aminotransferase measurement
0
8
16.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosaminyl (N-acetyl) transferase 4, core 2
VGNC:14450
739055
Mouse
MGI:2684919
218476
Dog
glucosaminyl (N-acetyl) transferase 4, core 2
488946
Horse
glucosaminyl (N-acetyl) transferase 4, core 2
100073285
Cow
glucosaminyl (N-acetyl) transferase 4, core 2
782825
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosaminyl (N-acetyl) transferase 4, core 2
Mouse
Dog
glucosaminyl (N-acetyl) transferase 4, core 2
Horse
glucosaminyl (N-acetyl) transferase 4, core 2
Cow
glucosaminyl (N-acetyl) transferase 4, core 2
Publication Statistics
PubMed Score 6.23
PubMed score by year
PubTator Score 2.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title