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Tbio
GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

Protein Summary
Description
Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396065
  • ENSP00000379377
  • ENSG00000140297
  • ENST00000560585
  • ENSP00000452741

Symbol
  • GNTM
  • C24GNT
  • C2GNT2
  • C2GNTM
  • C2/4GnT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.65
cellular component
0.59
cell line
0.57
gene perturbation
0.48
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.99   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.999030519
p_ni:  0.000969481
Score:  0.181
Data Source:  BioPlex,STRINGDB
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.991974938
p_ni:  0.008025015
p_wrong:  4.7e-8
Data Source:  BioPlex
CXCR4
Tclin
Family:  GPCR
Novelty:  0.0002811
p_int:  0.949620862
p_ni:  0.050363611
p_wrong:  0.000015527
Score:  0.199
Data Source:  BioPlex,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
p_int:  0.925076675
p_ni:  0.074923324
Score:  0.181
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.884973734
p_ni:  0.115026265
Data Source:  BioPlex
BCKDK
Tbio
Family:  Kinase
Novelty:  0.03296998
p_int:  0.808663216
p_ni:  0.191336784
Score:  0.204
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.762814087
p_ni:  0.237185913
Data Source:  BioPlex
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.963
Data Source:  STRINGDB
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
Score:  0.963
Data Source:  STRINGDB
B3GNT6
Tbio
Family:  Enzyme
Novelty:  0.13176407
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
67.3
neutrophil percentage of leukocytes
1
1
1
2.3
lymphocyte percentage of leukocytes
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
67.3
neutrophil percentage of leukocytes
1
2.3
lymphocyte percentage of leukocytes
1
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosaminyl (N-acetyl) transferase 3, mucin type
453482
Macaque
glucosaminyl (N-acetyl) transferase 3, mucin type
702754
Mouse
MGI:1919327
72077
Rat
RGD:631333
286976
Dog
glucosaminyl (N-acetyl) transferase 3, mucin type
487578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosaminyl (N-acetyl) transferase 3, mucin type
Macaque
glucosaminyl (N-acetyl) transferase 3, mucin type
Mouse
Rat
Dog
glucosaminyl (N-acetyl) transferase 3, mucin type
Publication Statistics
PubMed Score 32.99
PubMed score by year
PubTator Score 19.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title