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Tbio
GCNT2
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

Protein Summary
Description
Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. Isoform C: Determines the expression of the blood group I antigen in erythrocytes. This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265012
  • ENSP00000265012
  • ENSG00000111846
  • ENST00000316170
  • ENSP00000314844
  • ENST00000379597
  • ENSP00000368917
  • ENST00000495262
  • ENSP00000419411
  • ENST00000642698
  • ENSP00000495911
  • ENSG00000285222
  • ENST00000643503
  • ENSP00000493918
  • ENST00000644083
  • ENSP00000494927

Symbol
  • GCNT5
  • II
  • NACGT1
  • II
  • CCAT
  • IGNT
  • ULG3
  • GCNT5
  • GCNT2C
  • NACGT1
  • NAGCT1
  • CTRCT13
  • bA421M1.1
  • bA360O19.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
small molecule perturbation
0.83
transcription factor
0.82
biological process
0.75
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.36   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.36   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
TMEM79
Tbio
Novelty:  0.0624393
p_int:  0.999981895
p_ni:  2.12e-7
p_wrong:  0.000017893
Score:  0.261
Data Source:  BioPlex,STRINGDB
TRIM68
Tbio
Family:  Enzyme
Novelty:  0.11729189
p_int:  0.999943922
p_ni:  0.000056078
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
p_int:  0.999249383
p_ni:  0.000750617
Score:  0.219
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.994418226
p_ni:  0.005581774
Data Source:  BioPlex
COL14A1
Tbio
Novelty:  0.01760399
p_int:  0.982628917
p_ni:  0.017371083
Score:  0.154
Data Source:  BioPlex,STRINGDB
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.854464013
p_ni:  0.145478414
p_wrong:  0.000057573
Score:  0.183
Data Source:  BioPlex,STRINGDB
HLA-DPB1
Tbio
Novelty:  0.00185371
p_int:  0.839202841
p_ni:  0.160790997
p_wrong:  0.000006162
Data Source:  BioPlex
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.798198275
p_ni:  0.201801725
Score:  0.189
Data Source:  BioPlex,STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.953
Data Source:  STRINGDB
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Metabolic pathways
KEGG
Glycosphingolipid biosynthesis - lacto and neolacto series
Name
Explore in Pharos
Explore in Source
Metabolic pathways
Glycosphingolipid biosynthesis - lacto and neolacto series
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
2
3
84.9
monocyte count
3
2
3
84.9
monocyte percentage of leukocytes
2
2
2
77.9
monocyte percentage of leukocytes
2
2
2
77.9
lymphocyte count
2
2
2
53
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
84.9
monocyte count
3
84.9
monocyte percentage of leukocytes
2
77.9
monocyte percentage of leukocytes
2
77.9
lymphocyte count
2
53
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
697468
Mouse
MGI:1100870
14538
Rat
RGD:1303198
306860
Dog
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
488215
Horse
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B
100063291
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
Mouse
Rat
Dog
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Horse
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B
Publication Statistics
PubMed Score 29.36
PubMed score by year
PubTator Score 35.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title