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Tbio
GCN1
eIF-2-alpha kinase activator GCN1

Protein Summary
Description
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300648
  • ENSP00000300648
  • ENSG00000089154

Symbol
  • GCN1L1
  • KIAA0219
  • GCN1L
  • GCN1L1
  • PRIC295
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
BSG
Tbio
Novelty:  0.0010285
p_int:  0.988473498
p_ni:  0.011526502
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.969599158
p_ni:  0.030400842
Data Source:  BioPlex
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.955937332
p_ni:  0.044062668
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.922470742
p_ni:  0.077529258
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.914808837
p_ni:  0.085191163
Data Source:  BioPlex
C4orf3
Tbio
Novelty:  0.05950373
p_int:  0.894017152
p_ni:  0.105982848
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.878045167
p_ni:  0.121954833
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.79662634
p_ni:  0.20337366
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.788635612
p_ni:  0.211364388
Data Source:  BioPlex
EIF2AK4
Tchem
Family:  Kinase
Novelty:  0.00241683
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
7
7
90.5
serum gamma-glutamyl transferase measurement
1
1
1
51.7
heel bone mineral density
2
2
2
47.5
Left ventricular mass to end-diastolic volume ratio
1
1
1
40.7
mean corpuscular volume
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
7
90.5
serum gamma-glutamyl transferase measurement
1
51.7
heel bone mineral density
2
47.5
Left ventricular mass to end-diastolic volume ratio
1
40.7
mean corpuscular volume
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GCN1, eIF2 alpha kinase activator homolog
VGNC:5398
742053
Macaque
GCN1, eIF2 alpha kinase activator homolog
698528
Mouse
MGI:2444248
231659
Rat
RGD:1593434
690632
Dog
GCN1, eIF2 alpha kinase activator homolog
VGNC:41151
477505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GCN1, eIF2 alpha kinase activator homolog
Macaque
GCN1, eIF2 alpha kinase activator homolog
Mouse
Rat
Dog
GCN1, eIF2 alpha kinase activator homolog
Publication Statistics
PubMed Score 37.90
PubMed score by year
PubTator Score 7.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title