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Tbio
GCM1
Chorion-specific transcription factor GCMa

Protein Summary
Description
Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes (PubMed:10542267, PubMed:18160678). Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer (PubMed:10542267). Binds to the SYDE1 promoter (PubMed:27917469). Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (PubMed:19219068). This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259803
  • ENSP00000259803
  • ENSG00000137270

Symbol
  • GCMA
  • GCMA
  • hGCMa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.94
biological process
0.69
hub protein
0.67
gene perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.64   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.64   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
ERVW-1
Tbio
Novelty:  0.00038992
Score:  0.849
Data Source:  STRINGDB
ERVFRD-1
Tbio
Novelty:  0.02645962
Score:  0.829
Data Source:  STRINGDB
FBXW2
Tbio
Novelty:  0.01492058
Score:  0.827
Data Source:  STRINGDB
ASCL2
Tbio
Family:  TF
Novelty:  0.0090207
Score:  0.769
Data Source:  STRINGDB
SENP1
Tchem
Family:  Enzyme
Novelty:  0.00831213
Score:  0.696
Data Source:  STRINGDB
DUSP23
Tbio
Family:  Enzyme
Novelty:  0.06522366
Score:  0.686
Data Source:  STRINGDB
SYCP2L
Tdark
Novelty:  0.19013847
Score:  0.684
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.671
Data Source:  STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.647
Data Source:  STRINGDB
BAG2
Tbio
Novelty:  0.00924011
Score:  0.637
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
MGI
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
73.9
mean platelet volume
2
2
2
68.8
lymphocyte count
3
2
3
67.2
antisocial behaviour measurement
1
1
1
62.3
1
1
1
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
73.9
mean platelet volume
2
68.8
lymphocyte count
3
67.2
antisocial behaviour measurement
1
62.3
1
62.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glial cells missing homolog 1
VGNC:7180
472036
Macaque
glial cells missing homolog 1
709965
Mouse
MGI:108045
14531
Rat
RGD:61852
29394
Dog
glial cells missing homolog 1
VGNC:41149
481844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glial cells missing homolog 1
Macaque
glial cells missing homolog 1
Mouse
Rat
Dog
glial cells missing homolog 1
Publication Statistics
PubMed Score 107.64
PubMed score by year
PubTator Score 42.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title