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Tchem
GCLC
Glutamate--cysteine ligase catalytic subunit

Protein Summary
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229416
  • ENSP00000229416
  • ENSG00000001084
  • ENST00000650454
  • ENSP00000497574

Symbol
  • GLCL
  • GLCLC
  • GCL
  • GCS
  • GLCL
  • GLCLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.99
disease perturbation
0.98
biological process
0.96
transcription factor binding site profile
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.91   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 554.91   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0