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Tchem
GCLC
Glutamate--cysteine ligase catalytic subunit

Protein Summary
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229416
  • ENSP00000229416
  • ENSG00000001084
  • ENST00000650454
  • ENSP00000497574

Symbol
  • GLCL
  • GLCLC
  • GCL
  • GCS
  • GLCL
  • GLCLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.99
disease perturbation
0.98
biological process
0.96
transcription factor binding site profile
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.75   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.75   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (159)
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
p_int:  0.999999891
p_ni:  1.09e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TYW3
Tdark
Novelty:  0.15183348
p_int:  0.999695006
p_ni:  0.000304994
Score:  0.187
Data Source:  BioPlex,STRINGDB
NMD3
Tbio
Novelty:  0.03505289
p_int:  0.964135335
p_ni:  0.035502438
p_wrong:  0.000362227
Score:  0.297
Data Source:  BioPlex,STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.986
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.948
Data Source:  STRINGDB
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.938
Data Source:  STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
Score:  0.937
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.933
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.931
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.928
Data Source:  STRINGDB
Pathways (31)
Biological oxidations (R-HSA-211859)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Disease
Diseases of metabolism
Glutathione conjugation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
4
4
89.6
BMI-adjusted hip circumference
2
5
5
84.9
monocyte count
1
1
1
68.6
monocyte percentage of leukocytes
1
1
1
59.6
low density lipoprotein cholesterol measurement
1
1
1
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
4
89.6
BMI-adjusted hip circumference
5
84.9
monocyte count
1
68.6
monocyte percentage of leukocytes
1
59.6
low density lipoprotein cholesterol measurement
1
11.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate-cysteine ligase catalytic subunit
VGNC:8164
742732
Macaque
glutamate-cysteine ligase catalytic subunit
710508
Mouse
MGI:104990
14629
Rat
RGD:619868
25283
Dog
glutamate-cysteine ligase catalytic subunit
VGNC:41147
609822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate-cysteine ligase catalytic subunit
Macaque
glutamate-cysteine ligase catalytic subunit
Mouse
Rat
Dog
glutamate-cysteine ligase catalytic subunit
Publication Statistics
PubMed Score 484.75
PubMed score by year
PubTator Score 448.73
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title