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Tchem
GCK
Glucokinase

Protein Summary
Description
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancrea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345378
  • ENSP00000223366
  • ENSG00000106633
  • ENST00000395796
  • ENSP00000379142
  • ENST00000403799
  • ENSP00000384247
  • ENST00000616242
  • ENSP00000482149

Symbol
  • GK
  • GLK
  • HK4
  • HHF3
  • HKIV
  • HXKP
  • LGLK
  • MODY2
  • FGQTL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
phenotype
0.81
disease
0.8
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.86   (req: < 5)
Gene RIFs: 211   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.86   (req: >= 5)
Gene RIFs: 211   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 99
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0