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Tchem
GCK
Glucokinase

Protein Summary
Description
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancrea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345378
  • ENSP00000223366
  • ENSG00000106633
  • ENST00000395796
  • ENSP00000379142
  • ENST00000403799
  • ENSP00000384247
  • ENST00000616242
  • ENSP00000482149

Symbol
  • GK
  • GLK
  • HK4
  • HHF3
  • HKIV
  • HXKP
  • LGLK
  • MODY2
  • FGQTL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
phenotype
0.81
disease
0.8
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.23   (req: < 5)
Gene RIFs: 211   (req: <= 3)
Antibodies: 480   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 582.23   (req: >= 5)
Gene RIFs: 211   (req: > 3)
Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 98
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (246)
GCKR
Tchem
Family:  Enzyme
Novelty:  0.00798717
Score:  0.995
Data Source:  Reactome,STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.976
Data Source:  STRINGDB
G6PC
Tchem
Family:  Enzyme
Novelty:  0.00088094
Score:  0.973
Data Source:  STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.971
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.965
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.962
Data Source:  STRINGDB
G6PD
Tchem
Family:  Enzyme
Novelty:  0.00064455
Score:  0.959
Data Source:  STRINGDB
TREH
Tchem
Family:  Enzyme
Novelty:  0.00462386
Score:  0.946
Data Source:  STRINGDB
H6PD
Tbio
Novelty:  0.00366637
Score:  0.944
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.934
Data Source:  STRINGDB
Pathways (66)
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) (R-HSA-5619073)

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Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)
Reactome
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Reactome
Developmental Biology
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Developmental Biology
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
17
25
99.9
glucose measurement
7
16
17
99.8
fasting blood glucose measurement
12
7
18
99
birth weight
5
3
6
96.6
9
7
8
1.1
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
25
99.9
glucose measurement
17
99.8
fasting blood glucose measurement
18
99
birth weight
6
96.6
8
1.1
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucokinase
VGNC:7384
737923
Macaque
glucokinase
699728
Mouse
MGI:1270854
103988
Rat
RGD:2670
24385
Horse
glucokinase
100051836
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucokinase
Macaque
glucokinase
Mouse
Rat
Horse
glucokinase
Publication Statistics
PubMed Score 582.23
PubMed score by year
PubTator Score 1086.35
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title