Protein Summary
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth an ...more
- ENST00000375497
- ENSP00000364647
- ENSG00000115263
- ENST00000418842
- ENSP00000387662
- GLP1
- GLP2
- GRPP
- GLP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 0.98 | ||
chemical | 0.8 | ||
disease | 0.68 | ||
cellular component | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20968.4 (req: < 5)
Gene RIFs: 242 (req: <= 3)
Antibodies: 1735 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20968.4 (req: >= 5)
Gene RIFs: 242 (req: > 3)
Antibodies: 1735 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 103
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (103)
Protein-Protein Interactions (518)
NDUFB8
Family: Enzyme
Novelty: 0.019021
p_int: 0.999999256
p_ni: 7.23e-7
p_wrong: 2.1e-8
Data Source: BioPlex
RMND5B
Novelty: 0.08447048
p_int: 0.998916546
p_ni: 5.86e-7
p_wrong: 0.001082868
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (32)
Reactome (18)
KEGG (5)
PathwayCommons (7)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (q) signalling events | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (4)
Components (4)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 1 | 1 | 1 | 53.3 | |||||
intelligence | 2 | 2 | 2 | 5.5 | 39.5 | ||||
cortical surface area measurement | 1 | 1 | 0 | 6.8 | 38.2 | ||||
reaction time measurement | 1 | 1 | 1 | 29 | |||||
1 | 1 | 0 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 1 | 53.3 | |||||
intelligence | 2 | 5.5 | 39.5 | ||||
cortical surface area measurement | 0 | 6.8 | 38.2 | ||||
reaction time measurement | 1 | 29 | |||||
0 | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glucagon | VGNC:439 | 100609153 | |||||
Mouse | MGI:95674 | 14526 | ||||||
Rat | RGD:2668 | 24952 | ||||||
Dog | glucagon | VGNC:41143 | 403571 | |||||
Horse | glucagon | VGNC:18274 | 100051551 | |||||
Publication Statistics
PubMed Score 20968.40
PubMed score by year
PubTator Score 2915.54
PubTator score by year
Related Publications
Text Mined References (286)
GeneRif Annotations (242)
Items per page:
0 of 0
PMID | Year | Title |
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