You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GCFC2
GC-rich sequence DNA-binding factor 2

Protein Summary
Description
Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons. The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321027
  • ENSP00000318690
  • ENSG00000005436
  • ENST00000409857
  • ENSP00000386552
  • ENST00000470503
  • ENSP00000474481
  • ENST00000541687
  • ENSP00000437767

Symbol
  • C2orf3
  • GCF
  • TCF9
  • GCF
  • TCF9
  • DNABF
  • C2orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
transcription factor binding site profile
0.74
histone modification site profile
0.71
transcription factor
0.7
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.13   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.13   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (222)
HDAC11
Tclin
Family:  Epigenetic
Novelty:  0.01015211
p_int:  0.999992217
p_ni:  0.000007783
Data Source:  BioPlex
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999959438
p_ni:  0.000040562
Score:  0.919
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999661316
p_ni:  0.000338684
Score:  0.921
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999366318
p_ni:  0.00063368
p_wrong:  1e-9
Data Source:  BioPlex
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999265239
p_ni:  0.000734761
Score:  0.909
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999230759
p_ni:  0.000768413
p_wrong:  8.28e-7
Score:  0.901
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.999199941
p_ni:  0.000800058
p_wrong:  1e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999141112
p_ni:  0.000857533
p_wrong:  0.000001354
Score:  0.901
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.997130196
p_ni:  0.002860112
p_wrong:  0.000009693
Score:  0.947
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.986416565
p_ni:  0.013559316
p_wrong:  0.000024119
Score:  0.22
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
21.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GC-rich sequence DNA-binding factor 2
VGNC:259
742221
Macaque
GC-rich sequence DNA-binding factor 2
716061
Mouse
MGI:2141656
330361
Rat
RGD:1304792
312474
Dog
GC-rich sequence DNA-binding factor 2
VGNC:41142
483094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GC-rich sequence DNA-binding factor 2
Macaque
GC-rich sequence DNA-binding factor 2
Mouse
Rat
Dog
GC-rich sequence DNA-binding factor 2
Publication Statistics
PubMed Score 27.13
PubMed score by year
PubTator Score 123.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title