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Tbio
GCC1
GRIP and coiled-coil domain-containing protein 1

Protein Summary
Description
Probably involved in maintaining Golgi structure. The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321407
  • ENSP00000318821
  • ENSG00000179562

Symbol
  • GCC1P
  • GCC88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.75
histone modification site profile
0.72
disease perturbation
0.62
microRNA
0.61
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.79   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999999917
p_ni:  9e-9
p_wrong:  7.4e-8
Data Source:  BioPlex
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
SCOC
Tbio
Novelty:  0.05277646
p_int:  0.999971831
p_ni:  0.000028163
p_wrong:  6e-9
Score:  0.381
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999965059
p_ni:  0.000030942
p_wrong:  0.000003999
Score:  0.179
Data Source:  BioPlex,STRINGDB
GOLGA1
Tbio
Novelty:  0.02142224
Score:  0.981
Data Source:  STRINGDB
GOLGA4
Tbio
Novelty:  0.01363253
Score:  0.981
Data Source:  STRINGDB
TGOLN2
Tbio
Novelty:  0.005107
Score:  0.965
Data Source:  STRINGDB
STX16
Tbio
Novelty:  0.02462523
Score:  0.963
Data Source:  STRINGDB
ARL1
Tbio
Family:  Enzyme
Novelty:  0.29930049
Score:  0.959
Data Source:  STRINGDB
TMF1
Tbio
Novelty:  0.02543575
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
4
1
1.3
97.7
intelligence
3
10
5
6
70.9
risk-taking behaviour
1
1
1
67.7
worry measurement
1
2
0
5.8
32.6
Cleft palate
1
1
0
1.2
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
97.7
intelligence
5
6
70.9
risk-taking behaviour
1
67.7
worry measurement
0
5.8
32.6
Cleft palate
0
1.2
28.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRIP and coiled-coil domain containing 1
VGNC:4366
463697
Macaque
GRIP and coiled-coil domain containing 1
697975
Mouse
MGI:1921625
74375
Rat
RGD:2319954
100361513
Dog
GRIP and coiled-coil domain containing 1
VGNC:41139
482269
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRIP and coiled-coil domain containing 1
Macaque
GRIP and coiled-coil domain containing 1
Mouse
Rat
Dog
GRIP and coiled-coil domain containing 1
Publication Statistics
PubMed Score 11.79
PubMed score by year
PubTator Score 12.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title