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Tbio
GCAT
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

Protein Summary
Description
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248924
  • ENSP00000248924
  • ENSG00000100116
  • ENST00000323205
  • ENSP00000371110

Symbol
  • KBL
  • KBL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.9
protein domain
0.85
virus perturbation
0.72
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
EMB
Tbio
Novelty:  0.00135577
p_int:  0.979520648
p_ni:  0.002625768
p_wrong:  0.017853584
Score:  0.228
Data Source:  BioPlex,STRINGDB
LONP1
Tbio
Family:  Enzyme
Novelty:  0.00334137
p_int:  0.972037857
p_ni:  0.027962142
p_wrong:  1e-9
Score:  0.543
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.926278902
p_ni:  0.073638916
p_wrong:  0.000082182
Score:  0.196
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.853228748
p_ni:  0.146771252
Score:  0.328
Data Source:  BioPlex,STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
Score:  0.958
Data Source:  STRINGDB
GLDC
Tbio
Family:  Enzyme
Novelty:  0.00900467
Score:  0.957
Data Source:  STRINGDB
SHMT1
Tbio
Family:  Enzyme
Novelty:  0.00200739
Score:  0.938
Data Source:  STRINGDB
GATM
Tbio
Family:  Enzyme
Novelty:  0.00340356
Score:  0.918
Data Source:  STRINGDB
GNMT
Tbio
Family:  Enzyme
Novelty:  0.01472757
Score:  0.913
Data Source:  STRINGDB
PIPOX
Tbio
Family:  Enzyme
Novelty:  0.04107707
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Threonine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Threonine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
2
2
72.4
sex hormone-binding globulin measurement
4
2
4
69.8
cup-to-disc ratio measurement
2
2
2
67.9
heel bone mineral density
2
1
2
67.1
intraocular pressure measurement
4
3
5
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
72.4
sex hormone-binding globulin measurement
4
69.8
cup-to-disc ratio measurement
2
67.9
heel bone mineral density
2
67.1
intraocular pressure measurement
5
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine C-acetyltransferase
VGNC:5265
458820
Macaque
glycine C-acetyltransferase
698811
Mouse
MGI:1349389
26912
Rat
RGD:1307291
366959
Dog
glycine C-acetyltransferase
VGNC:41138
481262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine C-acetyltransferase
Macaque
glycine C-acetyltransferase
Mouse
Rat
Dog
glycine C-acetyltransferase
Publication Statistics
PubMed Score 192.98
PubMed score by year
PubTator Score 32.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title