GCAT
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Protein Summary
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
- ENST00000248924
- ENSP00000248924
- ENSG00000100116
- ENST00000323205
- ENSP00000371110
- KBL
- KBL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.9 | ||
protein domain | 0.85 | ||
virus perturbation | 0.72 | ||
cell type or tissue | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.98 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.98 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (58)
EMB
Novelty: 0.00135577
p_int: 0.979520648
p_ni: 0.002625768
p_wrong: 0.017853584
Score: 0.228
Data Source: BioPlex,STRINGDB
LONP1
Family: Enzyme
Novelty: 0.00334137
p_int: 0.972037857
p_ni: 0.027962142
p_wrong: 1e-9
Score: 0.543
Data Source: BioPlex,STRINGDB
NDUFS6
Family: Enzyme
Novelty: 0.07910252
p_int: 0.926278902
p_ni: 0.073638916
p_wrong: 0.000082182
Score: 0.196
Data Source: BioPlex,STRINGDB
MCCC1
Family: Enzyme
Novelty: 0.01234441
p_int: 0.853228748
p_ni: 0.146771252
Score: 0.328
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (3)
KEGG (2)
PathwayCommons (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Threonine catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Threonine catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum albumin measurement | 1 | 2 | 2 | 72.4 | |||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 69.8 | |||||
cup-to-disc ratio measurement | 2 | 2 | 2 | 67.9 | |||||
heel bone mineral density | 2 | 1 | 2 | 67.1 | |||||
intraocular pressure measurement | 4 | 3 | 5 | 67.1 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum albumin measurement | 2 | 72.4 | |||||
sex hormone-binding globulin measurement | 4 | 69.8 | |||||
cup-to-disc ratio measurement | 2 | 67.9 | |||||
heel bone mineral density | 2 | 67.1 | |||||
intraocular pressure measurement | 5 | 67.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glycine C-acetyltransferase | VGNC:5265 | 458820 | |||||
Macaque | glycine C-acetyltransferase | 698811 | ||||||
Mouse | MGI:1349389 | 26912 | ||||||
Rat | RGD:1307291 | 366959 | ||||||
Dog | glycine C-acetyltransferase | VGNC:41138 | 481262 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glycine C-acetyltransferase | |||||
Macaque | glycine C-acetyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glycine C-acetyltransferase | |||||
Publication Statistics
PubMed Score 192.98
PubMed score by year
PubTator Score 32.16
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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