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Tbio
GCA
Grancalcin

Protein Summary
Description
Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000437150
  • ENSP00000394842
  • ENSG00000115271

Symbol
  • GCL
  • GCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
co-expressed gene
0.94
histone modification site profile
0.83
molecular function
0.67
PubMedID
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.89   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 221.89   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
TMEM255A
Tdark
Novelty:  1.03700118
p_int:  0.999949979
p_ni:  0.000049992
p_wrong:  2.9e-8
Score:  0.295
Data Source:  BioPlex,STRINGDB
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999587969
p_ni:  0.000412027
p_wrong:  3e-9
Data Source:  BioPlex
ICMT
Tchem
Family:  Enzyme
Novelty:  0.00706181
p_int:  0.992881276
p_ni:  0.007111013
p_wrong:  0.000007711
Score:  0.187
Data Source:  BioPlex,STRINGDB
CIR1
Tdark
Novelty:  0.31735301
p_int:  0.9851867
p_ni:  0.014804243
p_wrong:  0.000009058
Score:  0.253
Data Source:  BioPlex,STRINGDB
PARVA
Tbio
Novelty:  0.02736601
p_int:  0.98390941
p_ni:  0.015684411
p_wrong:  0.00040618
Score:  0.281
Data Source:  BioPlex,STRINGDB
SIGLECL1
Tdark
p_int:  0.972909862
p_ni:  0.02708985
p_wrong:  2.88e-7
Data Source:  BioPlex
NEU4
Tchem
Family:  Enzyme
Novelty:  0.02621605
p_int:  0.972458685
p_ni:  0.027541179
p_wrong:  1.36e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.957550522
p_ni:  0.042356217
p_wrong:  0.000093262
Data Source:  BioPlex
SYPL2
Tdark
Novelty:  0.03928948
p_int:  0.908438023
p_ni:  0.089101756
p_wrong:  0.00246022
Score:  0.219
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.811969847
p_ni:  0.187968837
p_wrong:  0.000061316
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.3
96
type 1 diabetes mellitus
3
3
0
1.2
94.5
type 2 diabetes mellitus
3
4
0
1.1
91.4
autoimmune thyroid disease
1
2
0
1.2
82.5
blood protein measurement
2
2
2
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
96
type 1 diabetes mellitus
0
1.2
94.5
type 2 diabetes mellitus
0
1.1
91.4
autoimmune thyroid disease
0
1.2
82.5
blood protein measurement
2
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
grancalcin
VGNC:438
459694
Macaque
grancalcin
702138
Mouse
MGI:1918521
227960
Rat
RGD:1306589
295647
Dog
grancalcin
VGNC:41137
608208
Species
Name
OMA
EggNOG
Inparanoid
Chimp
grancalcin
Macaque
grancalcin
Mouse
Rat
Dog
grancalcin
Publication Statistics
PubMed Score 221.89
PubMed score by year
PubTator Score 72.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title