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Tchem
GC
Vitamin D-binding protein

Protein Summary
Description
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation. The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273951
  • ENSP00000273951
  • ENSG00000145321
  • ENST00000504199
  • ENSP00000421725

Symbol
  • DBP
  • VDB
  • GRD3
  • VDBG
  • VDBP
  • GcMAF
  • DBP/GC
  • Gc-MAF
  • DBP-maf
  • HEL-S-51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.88
protein domain
0.85
cellular component
0.67
disease
0.65
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1698.53   (req: < 5)
Gene RIFs: 213   (req: <= 3)
Antibodies: 708   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1698.53   (req: >= 5)
Gene RIFs: 213   (req: > 3)
Antibodies: 708   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1