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Tbio
GBP5
Guanylate-binding protein 5

Protein Summary
Description
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370459
  • ENSP00000359488
  • ENSG00000154451

Symbol
  • GBP-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
molecular function
0.93
cell type or tissue
0.74
cell line
0.7
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.999999979
p_ni:  7e-9
p_wrong:  1.4e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
GBP1
Tbio
Novelty:  0.00634662
p_int:  0.999999834
p_ni:  1.22e-7
p_wrong:  4.4e-8
Score:  0.826
Data Source:  BioPlex,STRINGDB
CPEB1
Tbio
Novelty:  0.00444378
p_int:  0.999976175
p_ni:  0.000023815
p_wrong:  1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
ACSM1
Tbio
Family:  Enzyme
Novelty:  0.01901085
p_int:  0.999815863
p_ni:  0.000184131
p_wrong:  6e-9
Score:  0.829
Data Source:  BioPlex,STRINGDB
C1orf159
Tdark
Novelty:  1.78509526
p_int:  0.963083589
p_ni:  0.010217201
p_wrong:  0.02669921
Score:  0.309
Data Source:  BioPlex,STRINGDB
APOL2
Tbio
Novelty:  0.06076255
p_int:  0.934902466
p_ni:  0.062035741
p_wrong:  0.003061793
Score:  0.259
Data Source:  BioPlex,STRINGDB
SURF1
Tbio
Novelty:  0.00717605
p_int:  0.913617707
p_ni:  0.085113319
p_wrong:  0.001268974
Score:  0.19
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.881629464
p_ni:  0.118370534
p_wrong:  2e-9
Data Source:  BioPlex
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
clinical treatment
1
1
0
9
22.8
gut microbiome measurement
1
1
1
6.9
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
5225.1
5.5
educational attainment
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
clinical treatment
0
9
22.8
gut microbiome measurement
1
6.9
soluble triggering receptor expressed on myeloid cells 2 measurement
0
5225.1
5.5
educational attainment
1
4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2429943
229898
Rat
RGD:1311040
362050
Horse
guanylate binding protein 5
VGNC:18265
100052023
Cow
guanylate binding protein 5
516949
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
guanylate binding protein 5
Cow
guanylate binding protein 5
Publication Statistics
PubMed Score 49.62
PubMed score by year
PubTator Score 11.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title