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Tbio
GBP3
Guanylate-binding protein 3

Protein Summary
Description
Exhibits antiviral activity against influenza virus. This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.91
transcription factor perturbation
0.88
gene perturbation
0.85
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
GBP2
Tbio
Novelty:  0.01803054
p_int:  0.999999999
p_ni:  1e-9
Score:  0.876
Data Source:  BioPlex,STRINGDB
GBP1
Tbio
Novelty:  0.00634662
p_int:  0.999999996
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.953
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.95
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.947
Data Source:  STRINGDB
OAS3
Tbio
Family:  Enzyme
Novelty:  0.02422229
Score:  0.94
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.937
Data Source:  STRINGDB
OAS1
Tbio
Family:  Enzyme
Novelty:  0.00532331
Score:  0.935
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.928
Data Source:  STRINGDB
TRIM22
Tbio
Family:  Enzyme
Novelty:  0.0221032
Score:  0.927
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
38.8
blood urea nitrogen measurement
1
1
1
27.9
serum metabolite measurement
1
1
1
18.9
lymphocyte count
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
38.8
blood urea nitrogen measurement
1
27.9
serum metabolite measurement
1
18.9
lymphocyte count
1
5.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 3
VGNC:1243
457000
Macaque
guanylate binding protein 3
694283
Dog
guanylate binding protein 1
490172
Horse
guanylate-binding protein 1
100052081
Cow
guanylate-binding protein 1
511531
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate binding protein 3
Macaque
guanylate binding protein 3
Dog
guanylate binding protein 1
Horse
guanylate-binding protein 1
Cow
guanylate-binding protein 1
Publication Statistics
PubMed Score 14.52
PubMed score by year
PubTator Score 10.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title