Tbio GBP1 Guanylate-binding protein 1

Protein Summary

Description

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32455
• D3DT26
• Q5T8M1

Gene Name

• GBP1

Ensembl ID

• ENST00000370473
• ENSP00000359504
• ENSG00000117228

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
virus perturbation	1
molecular function	0.93
transcription factor perturbation	0.8
small molecule perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanylate-binding Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanylate-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (222)

Explore Interacting Targets

1 – 10 of 222

• See Interactions on String-DB

GBP3

Tbio

Novelty:  0.06761345

p_int:  0.999999996

p_ni:  3e-9

p_wrong:  1e-9

Score:  0.893

Data Source:  BioPlex,STRINGDB

GBP5

Tbio

Novelty:  0.03705719

p_int:  0.999999834

p_ni:  1.22e-7

p_wrong:  4.4e-8

Score:  0.826

Data Source:  BioPlex,STRINGDB

GBP2

Tbio

Novelty:  0.01803054

p_int:  0.999999388

p_ni:  6.12e-7

Score:  0.937

Data Source:  BioPlex,STRINGDB

ESR1

Tclin

Family:  NR

Novelty:  0.00005938

p_int:  0.999302822

p_ni:  0.000697103

p_wrong:  7.5e-8

Score:  0.284

Data Source:  BioPlex,STRINGDB

RNF31

Tbio

Family:  Enzyme

Novelty:  0.01394304

p_int:  0.993644635

p_ni:  0.006336536

p_wrong:  0.000018828

Score:  0.193

Data Source:  BioPlex,STRINGDB

AFM

Tbio

Novelty:  0.00607207

p_int:  0.993644635

p_ni:  0.006336536

p_wrong:  0.000018828

Score:  0.192

Data Source:  BioPlex,STRINGDB

UTP6

Tbio

Novelty:  0.06525007

p_int:  0.976820485

p_ni:  0.023146135

p_wrong:  0.00003338

Score:  0.207

Data Source:  BioPlex,STRINGDB

GNB2

Tbio

Novelty:  0.08682553

p_int:  0.80010322

p_ni:  0.199896686

p_wrong:  9.4e-8

Data Source:  BioPlex

TRIM22

Tbio

Family:  Enzyme

Novelty:  0.0221032

Score:  0.978

Data Source:  STRINGDB

IRF1

Tbio

Family:  TF

Novelty:  0.00099983

Score:  0.974

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

WikiPathways (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interferon Signaling	280 targets	R-HSA-913531
Reactome	Interferon gamma signaling	172 targets	R-HSA-877300

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interferon Signaling	280 targets	R-HSA-913531
Interferon gamma signaling	172 targets	R-HSA-877300

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (32)

Functions (10)

Components (8)

Processes (14)

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GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	UniProtKB
GDP binding	Inferred from Direct Assay (IDA)	CAFA
GTP binding	Inferred from Direct Assay (IDA)	CAFA
GTPase activity	Inferred from Direct Assay (IDA)	CAFA
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
cytokine binding	Inferred from Physical Interaction (IPI)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
Hsp90 protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
spectrin binding	Inferred from Physical Interaction (IPI)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	1	1	1		49.5
blood urea nitrogen measurement	EFO_0004741	1	1	1		21.5

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	1		49.5
blood urea nitrogen measurement	EFO_0004741	1		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Antiviral defense
Cell membrane
Complete proteome
Cytoplasm
Golgi apparatus
GTP-binding
Hydrolase
Immunity
Lipoprotein

GWAS Trait Find Similar Targets

No Header	No Header
blood urea nitrogen measurement
BMI-adjusted waist circumference

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	guanylate binding protein 1	VGNC:6829	738075
Macaque	guanylate binding protein 2		694684
Mouse	guanylate binding protein 2b	MGI:95666	14468
Rat	guanylate binding protein 1	RGD:1311877	304266
Dog	guanylate binding protein 1		490172

Species	Name	OMA	EggNOG	Inparanoid
Chimp	guanylate binding protein 1
Macaque	guanylate binding protein 2
Mouse	guanylate binding protein 2b
Rat	guanylate binding protein 1
Dog	guanylate binding protein 1

Publication Statistics

PubMed Score 190.78

PubMed score by year

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PubTator Score 100.06

PubTator score by year

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Related Publications

Text Mined References (68)

GeneRif Annotations (58)

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PMID	Year	Title