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Tbio
GBGT1
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens. This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372040
  • ENSP00000361110
  • ENSG00000148288
  • ENST00000372043
  • ENSP00000361113
  • ENST00000540636
  • ENSP00000437663

Symbol
  • FS
  • A3GALNT
  • UNQ2513
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.71
metabolite
0.62
cellular component
0.6
gene perturbation
0.59
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
B3GALNT1
Tbio
Family:  Enzyme
Novelty:  0.01235828
Score:  0.957
Data Source:  STRINGDB
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
Score:  0.941
Data Source:  STRINGDB
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.902
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.9
Data Source:  STRINGDB
GALNT8
Tbio
Family:  Enzyme
Novelty:  0.19956817
Score:  0.866
Data Source:  STRINGDB
GALNT4
Tbio
Family:  Enzyme
Novelty:  0.05200323
Score:  0.851
Data Source:  STRINGDB
GALNT9
Tbio
Family:  Enzyme
Novelty:  0.14674534
Score:  0.848
Data Source:  STRINGDB
GALNT10
Tchem
Family:  Enzyme
Novelty:  0.065869
Score:  0.846
Data Source:  STRINGDB
GALNTL6
Tbio
Family:  Enzyme
Novelty:  0.26774606
Score:  0.844
Data Source:  STRINGDB
GALNTL5
Tbio
Family:  Enzyme
Novelty:  0.17882969
Score:  0.836
Data Source:  STRINGDB
Pathways (4)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Metabolic pathways
KEGG
Glycosphingolipid biosynthesis - globo and isoglobo series
Name
Explore in Pharos
Explore in Source
Metabolic pathways
Glycosphingolipid biosynthesis - globo and isoglobo series
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (127)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
5
2
1.4
99.6
von Willebrand factor measurement
3
4
2
13.5
99.5
factor VIII measurement
2
2
3
17.7
98.7
coagulation factor measurement
1
2
2
98.5
alkaline phosphatase measurement
2
3
3
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.4
99.6
von Willebrand factor measurement
2
13.5
99.5
factor VIII measurement
3
17.7
98.7
coagulation factor measurement
2
98.5
alkaline phosphatase measurement
3
98.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
VGNC:4750
464823
Mouse
MGI:2449143
227671
Dog
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
403833
Horse
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
VGNC:53567
100069388
Cow
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
618517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Mouse
Dog
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
Horse
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Cow
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
Publication Statistics
PubMed Score 17.85
PubMed score by year
PubTator Score 7.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title