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Tdark
GATD3A
Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial

Protein Summary
Description
This gene encodes a potential mitochondrial protein that is a member of the DJ-1/PfpI gene family. This protein is overexpressed in fetal Down syndrome brain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291577
  • ENSP00000291577
  • ENSG00000160221
  • ENST00000348499
  • ENSP00000344901

Symbol
  • C21orf33
  • ES1
  • HES1
  • KNPH
  • KNPI
  • GATD3
  • GT335
  • C21orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.97   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.97   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.754260626
p_ni:  0.245739374
Score:  0.188
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
Score:  0.897
Data Source:  STRINGDB
NAT1
Tchem
Family:  Enzyme
Novelty:  0.00425955
Score:  0.792
Data Source:  STRINGDB
NAT2
Tbio
Family:  Enzyme
Novelty:  0.00150849
Score:  0.788
Data Source:  STRINGDB
GLS
Tchem
Family:  Enzyme
Novelty:  0.00321692
Score:  0.624
Data Source:  STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
Score:  0.585
Data Source:  STRINGDB
EWSR1
Tbio
Novelty:  0.00068411
Score:  0.568
Data Source:  STRINGDB
TTLL4
Tbio
Family:  Enzyme
Novelty:  0.14127442
Score:  0.567
Data Source:  STRINGDB
IFT88
Tbio
Novelty:  0.00727114
Score:  0.56
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.556
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
90.1
Addison disease
1
2
0
2.8
88.2
eosinophil count
3
2
3
85.1
eosinophil percentage of leukocytes
2
2
2
82.2
1
1
0
1.1
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.1
Addison disease
0
2.8
88.2
eosinophil count
3
85.1
eosinophil percentage of leukocytes
2
82.2
0
1.1
77.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chromosome 3 open reading frame, human C21orf33
713055
Mouse
MGI:1351861
28295
Rat
RGD:1303003
294326
Cow
chromosome 1 open reading frame, human C21orf33
514335
Pig
chromosome 13 C21orf33 homolog
100623793
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chromosome 3 open reading frame, human C21orf33
Mouse
Rat
Cow
chromosome 1 open reading frame, human C21orf33
Pig
chromosome 13 C21orf33 homolog
Publication Statistics
PubMed Score 222.97
PubMed score by year
PubTator Score 73.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title